University of Massachusetts Medical School, Worcester, MA 01655, USA.
J Am Acad Child Adolesc Psychiatry. 2011 Aug;50(8):807-17.e8. doi: 10.1016/j.jaac.2011.05.001. Epub 2011 Jul 13.
A potentially useful tool for understanding the distribution and determinants of emotional dysregulation in children is a Child Behavior Checklist profile, comprising the Attention Problems, Anxious/Depressed, and Aggressive Behavior clinical subscales (CBCL-DP). The CBCL-DP indexes a heritable trait that increases susceptibility for later psychopathology, including severe mood problems and aggressive behavior. We have conducted a genome-wide association study of the CBCL-DP in children with attention-deficit/hyperactivity disorder (ADHD).
Families were ascertained at Massachusetts General Hospital and University of California, Los Angeles. Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. Genome-wide association analyses were conducted with the MQFAM multivariate extension of PLINK.
CBCL data were available for 341 ADHD offspring from 339 ADHD affected trio families from the UCLA (N = 128) and the MGH (N = 213) sites. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: TMEM132D, LRRC7, SEMA3A, ALK, and STIP1.
We found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP.
理解儿童情绪失调的分布和决定因素的一种潜在有用的工具是儿童行为检查表（CBCL）剖面图，它包含注意问题、焦虑/抑郁和攻击行为临床子量表（CBCL-DP）。CBCL-DP 指标是一种遗传性特征，增加了以后发生精神病理学的易感性，包括严重的情绪问题和攻击行为。我们对注意力缺陷多动障碍（ADHD）儿童的 CBCL-DP 进行了全基因组关联研究。
在马萨诸塞州综合医院和加利福尼亚大学洛杉矶分校确定了家族。使用 Illumina Human1M 或 Human1M-Duo BeadChip 平台进行基因分型。使用 PLINK 的 MQFAM 多变量扩展进行全基因组关联分析。
UCLA（N=128）和 MGH（N=213）站点的 339 个 ADHD 受影响的三胞胎家庭中，有 341 个 ADHD 后代的 CBCL 数据可用。我们没有发现全基因组统计学上显著的关联，但在 p < 5E-05 处确定了几个可能的候选基因：TMEM132D、LRRC7、SEMA3A、ALK 和 STIP1。
我们发现了与 CBCL-DP 相关的发育表达基因的提示性证据，这些基因与海马依赖记忆和学习有关。
