补充早产儿配方对新生儿重症监护病房出院后胰岛素敏感性和身体成分的影响。

Benefits of supplemented preterm formulas on insulin sensitivity and body composition after discharge from the neonatal intensive care unit.

机构信息

Neonatology Unit, Hospital Dr Sótero del Rio, Santiago, Chile.

出版信息

J Pediatr. 2011 Dec;159(6):926-32.e2. doi: 10.1016/j.jpeds.2011.06.002. Epub 2011 Jul 23.

DOI:10.1016/j.jpeds.2011.06.002

PMID:21784447

Abstract

OBJECTIVE

To evaluate body composition and fasting insulin level in preterm infants receiving preterm formulas (higher protein plus docosahexaenoic acid) for longer periods compared with a recent historical cohort receiving these formulas for shorter periods.

STUDY DESIGN

A total of 95 infants fed preterm formula for 6 months or longer (postdischarge formula group) and 87 infants fed preterm formula only during their hospital stay (hospital formula group) were included in this arm of the study.

RESULTS

Bone mineral density, content, and lean mass were not different at 1 year and 2 years. However, in the postdischarge formula group, total fat mass (%) was lower by the second year (19.3% ± 5.3% vs 21.7% ± 4.2%; P < .01), trunk fat was lower by the first year (14.7% ± 5.0% vs 16.9% ± 4.9%; P < .005) and at the second year (14.1% ± 5.7% vs 17.2% ± 4.7%; P < .001), and fasting insulin was lower by the first year (13.2% ± 7.1% vs 17.2% ± 13.6% mIU/L; P = .06) and at the second year (13.6% ± 6.1% vs 26.4% ± 14.2%; P < .001).

CONCLUSION

Preterm infants fed formulas enriched with docosahexaenoic acid may have a better subsequent metabolic profile.

摘要

目的

评估接受添加了蛋白质和二十二碳六烯酸（DHA）的早产儿配方奶粉时间更长的早产儿与接受相同配方奶粉时间更短的近期历史队列相比的身体成分和空腹胰岛素水平。

研究设计

共有 95 名接受早产儿配方奶粉喂养 6 个月或更长时间（出院后配方奶粉组）和 87 名仅在住院期间接受早产儿配方奶粉的婴儿（住院配方奶粉组）被纳入本研究的这一部分。

结果

1 年和 2 年后骨矿物质密度、含量和瘦体重没有差异。然而，在出院后配方奶粉组中，第二年总脂肪量（%）较低（19.3%±5.3%比 21.7%±4.2%；P<.01），第一年躯干脂肪量较低（14.7%±5.0%比 16.9%±4.9%；P<.005），第二年也较低（14.1%±5.7%比 17.2%±4.7%；P<.001），空腹胰岛素水平第一年较低（13.2%±7.1%比 17.2%±13.6%mIU/L；P=0.06），第二年也较低（13.6%±6.1%比 26.4%±14.2%；P<.001）。