Meyer L S, Kotch L E, Riley E P
Center for Behavioral Teratology, Psychology Department, State University of New York-Albany 12222.
Alcohol Clin Exp Res. 1990 Feb;14(1):23-7. doi: 10.1111/j.1530-0277.1990.tb00440.x.
Walking patterns were assessed in rats that had been exposed to alcohol neonatally during a period encompassing the brain growth spurt. Rat pups were exposed via an artificial rearing technique to either a 2.50% (w/v) or 2.15% (w/v) EtOH-milk formula on Days 26-32 postconception. An artificially reared control group and a suckle-control group were also included in the experiment. Gait patterns were assessed in animals from each of the neonatal treatment groups at 43, 67, and 87 days postconception. No differences in gait patterns were evident on Day 43 postconception; however, on Days 67 and 87 animals exposed to alcohol during the neonatal period displayed an abnormal gait. These animals had a shortened stride length and an increased angle of placement of the hindfeet relative to artificially reared and suckle-control animals. The altered gait pattern may be the result of alcohol-induced hippocampal and cerebellar damage during the brain growth spurt.
在围大脑发育加速期经新生儿期酒精暴露的大鼠中评估行走模式。在受孕后第26 - 32天，通过人工饲养技术将幼鼠暴露于2.50%（w/v）或2.15%（w/v）乙醇 - 牛奶配方中。实验还包括人工饲养对照组和哺乳对照组。在受孕后43、67和87天对每个新生儿治疗组的动物进行步态模式评估。在受孕后第43天，步态模式没有明显差异；然而，在第67天和第87天，新生儿期暴露于酒精的动物表现出异常步态。这些动物的步幅缩短，相对于人工饲养和哺乳对照动物，后足放置角度增加。步态模式的改变可能是大脑发育加速期酒精诱导的海马体和小脑损伤的结果。
