Elliott James W, Blackwood Laura
University of Liverpool, Small Animal Teaching Hospital, Leahurst, Neston CH64 7TE, UK.
J Feline Med Surg. 2011 Oct;13(10):712-7. doi: 10.1016/j.jfms.2011.06.005. Epub 2011 Jul 23.
Anal sac adenocarcinoma is uncommon in cats. We report the outcome of multi-modality therapy in two cats (surgery, definitive radiotherapy and systemic chemotherapy) and surgery alone in two cats. All received surgical excision of the primary tumour followed by radiotherapy and carboplatin chemotherapy in two cases. Both cats that underwent multimodal therapy developed distant metastatic disease and one developed recurrence of the primary tumour. One cat that underwent surgery alone with incomplete margins also developed rapid recurrence. Overall survival times were 89, 161 and 169 days. One cat that had complete surgical excision is still alive without recurrence 425 days postoperatively. Whilst the role of radiation in the local control of this disease is yet to be defined, clearly a more effective systemic therapy is required before such aggressive local treatment can be routinely recommended.
肛门囊腺癌在猫中并不常见。我们报告了两只猫接受多模式治疗（手术、根治性放疗和全身化疗）以及另外两只猫仅接受手术的治疗结果。所有猫均接受了原发性肿瘤的手术切除，其中两例随后接受了放疗和卡铂化疗。接受多模式治疗的两只猫均发生了远处转移，其中一只出现了原发性肿瘤复发。一只手术切缘不完整且仅接受手术的猫也迅速复发。总生存时间分别为89天、161天和169天。一只接受了完整手术切除的猫在术后425天仍存活且未复发。虽然放疗在这种疾病的局部控制中的作用尚未明确，但显然在常规推荐这种积极的局部治疗之前，需要一种更有效的全身治疗方法。
