Department of Radiology, Division of Pediatric Radiology, Lucile Salter Packard Children's Hospital, 725 Welch Rd, Palo Alto, CA 94304, USA.
AJR Am J Roentgenol. 2011 Aug;197(2):308-17. doi: 10.2214/AJR.11.6953.
The purposes of this review are to describe the signaling pathways of and the cellular changes that occur with apoptosis and other forms of cell death, summarize tracers and modalities used for imaging of apoptosis, delineate the relation between apoptosis and inhibition of protein translation, and describe spectroscopic technologies that entail high-frequency ultrasound and infrared and midinfrared light in characterizing the intracellular events of apoptosis.
Apoptosis is a highly orchestrated set of biochemical and morphologic cellular events. These events present many potential targets for the imaging of apoptosis in vivo. Imaging of apoptosis can facilitate early assessment of anticancer treatment before tumor shrinkage, which may increase the effectiveness of delivery of chemotherapy and radiation therapy and speed drug development.
本综述旨在描述细胞凋亡和其他形式细胞死亡的信号通路及细胞变化，总结用于细胞凋亡成像的示踪剂和方式，阐述细胞凋亡与蛋白质翻译抑制之间的关系，并描述涉及高频超声、近红外和中红外光的光谱技术，以描述细胞凋亡的细胞内事件。
细胞凋亡是一组高度协调的生化和形态学细胞事件。这些事件为体内细胞凋亡成像提供了许多潜在的靶点。细胞凋亡成像可以在肿瘤缩小之前促进对癌症治疗的早期评估，这可能会提高化疗和放疗的疗效，并加快药物开发。
