Kerrebijn K F
Division of Paediatric Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands.
Am Rev Respir Dis. 1990 Feb;141(2 Pt 2):S77-81.
Various aspects of topical corticosteroids in the treatment of childhood asthma are reviewed: indications, application and bioavailability, dosing schedules, clinical efficacy, effects on non-specific bronchial hyperresponsiveness, bronchial reactions after allergen challenge, and exercise-induced bronchoconstriction, as well as possible side effects such as the influences on the hypothalamic-pituitary-adrenal axis or growth and other potentially harmful actions. It was concluded that topical corticosteroids are very beneficial in the treatment of moderate-to-severe childhood asthma and that the risk of side effects can be neglected when the required doses for most patients are used.
适应证、应用与生物利用度、给药方案、临床疗效、对非特异性支气管高反应性的影响、过敏原激发后的支气管反应以及运动诱发的支气管收缩，还有可能的副作用，如下丘脑-垂体-肾上腺轴、生长及其他潜在有害作用的影响。得出的结论是，局部用皮质类固醇对中重度儿童哮喘的治疗非常有益，且当使用大多数患者所需剂量时，副作用风险可忽略不计。
