Parker D R, O'Connor G T, Sparrow D, Segal M R, Weiss S T
Normative Aging Study, Veterans Administration Outpatient Clinic, Boston, Massachusetts.
Am Rev Respir Dis. 1990 Mar;141(3):589-94. doi: 10.1164/ajrccm/141.3.589.
Nonspecific airway hyperresponsiveness and atopy have been postulated to be risk factors that predispose individuals to the development of chronic obstructive pulmonary disease. The purpose of the present study was to examine the relationship of methacholine airway responsiveness and markers of atopy to rate of decline in lung function among 790 men, age 40 to 79 yr, followed in the Normative Aging Study. Airway responsiveness was assessed at the end of follow-up, which ranged from 14 to 24 yr. Multiple linear regression analysis indicated that greater methacholine airway responsiveness was associated with more rapid annual FEV1 decline. Stratified analysis suggested that this association was stronger among skin test-negative, current smokers. No significant relationship was found between serum IgE level and annual FEV1 decline. A weak but statistically significant correlation between eosinophil count and mean annual FEV1 decline was noted among skin test-negative individuals (r = -0.08; p = 0.03). Results from the present study do not show a clear association between atopy and decline in FEV1. These data, however, do indicate an independent association between heightened methacholine responsiveness on decline in FEV1 in adult males.
非特异性气道高反应性和特应性被认为是使个体易患慢性阻塞性肺疾病的危险因素。本研究的目的是在规范衰老研究中，调查790名年龄在40至79岁之间男性的乙酰甲胆碱气道反应性和特应性标志物与肺功能下降速率之间的关系。气道反应性在随访结束时进行评估，随访时间为14至24年。多元线性回归分析表明，乙酰甲胆碱气道反应性越高，FEV1年下降速度越快。分层分析表明，这种关联在皮肤试验阴性的当前吸烟者中更强。未发现血清IgE水平与FEV1年下降之间存在显著关系。在皮肤试验阴性的个体中，嗜酸性粒细胞计数与FEV1平均年下降之间存在微弱但具有统计学意义的相关性（r = -0.08；p = 0.03）。本研究结果未显示特应性与FEV1下降之间存在明确关联。然而，这些数据确实表明，成年男性乙酰甲胆碱反应性增强与FEV1下降之间存在独立关联。
