Shadick N A, Sparrow D, O'Connor G T, DeMolles D, Weiss S T
Department of Veterans Affairs Outpatient Clinic, Boston, Massachusetts, USA.
Thorax. 1996 Aug;51(8):787-92. doi: 10.1136/thx.51.8.787.
Previous reports on the relationship between serum immunoglobulin E (IgE) concentration and the level and rate of decline of pulmonary function in the general population have produced conflicting results. The relationship between total serum IgE concentration and pulmonary function was therefore examined in 1078 men aged 41-86 years followed in the Normative Aging Study.
The serum IgE concentration determined at the start of the three year follow up period was examined in relation to both the level and longitudinal rate of decline of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC.
In a cross sectional analysis restricted to subjects who had ever smoked cigarettes, multiple linear regression models indicated an inverse association between total serum IgE concentration and both FEV1 (beta = -0.090 1/log10 IU/ml; SE = 0.030; p < 0.005) and FVC (beta = -0.110 1/log10 IU/ml; SE = 0.034; p < 0.005) but not FEV1/FVC, after adjustment for age and height. This relationship persisted when individuals with diagnosed asthma or methacholine hyperresponsiveness were excluded. In subjects who had never smoked cigarettes the total serum IgE concentration was unrelated to spirometric indices. No association was observed in smokers or non-smokers between the serum IgE concentration measured at the beginning of the period of follow up and the decline in FEV1, FVC, or FEV1/FVC.
Increased levels of serum IgE measured at the beginning of the follow up period are associated with lower levels of pulmonary function but are not predictive of an accelerated rate in the decline of pulmonary function among middle aged and older men.
既往关于普通人群血清免疫球蛋白E（IgE）浓度与肺功能水平及下降速率之间关系的报告结果相互矛盾。因此，在“规范衰老研究”中对1078名年龄在41 - 86岁的男性进行了血清总IgE浓度与肺功能关系的研究。
在三年随访期开始时测定的血清IgE浓度与一秒用力呼气容积（FEV1）、用力肺活量（FVC）及FEV1/FVC的水平和纵向下降速率进行了相关性分析。
在仅限于曾经吸烟的受试者的横断面分析中，多元线性回归模型显示，在调整年龄和身高后，血清总IgE浓度与FEV1（β = -0.090 1/log10 IU/ml；标准误 = 0.030；p < 0.005）和FVC（β = -0.110 1/log10 IU/ml；标准误 = 0.034；p < 0.005）均呈负相关，但与FEV1/FVC无关。排除诊断为哮喘或对乙酰甲胆碱高反应性的个体后，这种关系依然存在。在从不吸烟的受试者中，血清总IgE浓度与肺量计指标无关。在吸烟者或不吸烟者中，随访期开始时测得的血清IgE浓度与FEV1、FVC或FEV1/FVC的下降之间均未观察到相关性。
随访期开始时测得的血清IgE水平升高与较低的肺功能水平相关，但不能预测中年及老年男性肺功能下降速率的加快。
