Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.
Nat Neurosci. 2011 Jul 24;14(9):1118-20. doi: 10.1038/nn.2880.
The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.
丘脑网状核（TRN）被假设调节新皮层节律和行为状态。通过在行为小鼠中使用光遗传学和多电极记录，我们发现 TRN 的短暂选择性驱动将丘脑皮质放电模式从紧张变为爆发，并产生与状态相关的新皮层纺锤波。这些发现为 TRN 在体内状态调节中的参与提供了因果支持，并引入了一种新的模型来解决该结构在行为中的作用。
