Pagano N, Arosio M, Romeo F, Rando G, Del Conte G, Carlino A, Strangio G, Vitetta E, Malesci A, Repici A
Dipartimento di Gastroenterologia, Istituto Clinico Humanitas, Via Manzoni 56, MI, 20089 Rozzano, Milano, Italy.
Diagn Ther Endosc. 2011;2011:542159. doi: 10.1155/2011/542159. Epub 2011 Jul 12.
Introduction and aims. Balanced propofol sedation (BPS) administered by gastroenterologists has gained popularity in endoscopic procedures. Few studies exist about the safety of this approach during endosonography with fine needle aspiration (EUS-FNA). We assessed the safety of BPS in EUS-FNA. Materials and methods. 112 consecutive patients, referred to our unit to perform EUS-FNA, from February 2008 to December 2009, were sedated with BPS. A second gastroenterologist administered the drugs and monitorized the patient. Results. All the 112 patients (62 males, mean age 58.35) completed the examination. The mean dose of midazolam and propofol was, respectively, of 2.1 mg (range 1-4 mg) and 350 mg (range 180-400). All patients received oxygen with a mean flux of 4 liter/minute (range 2-6 liters/minute). The mean recovery time after procedure was 25 minutes (range 18-45 minutes). No major complications related to sedation were registered during all procedures. The oxygen saturation of all patients never reduced to less than 85%. Blood systolic pressure during and after the procedure never reduced to less than 100 mmHg. Conclusions. In our experience BPS administered by non-anaesthesiologists provided safe and successful sedation in patients undergoing EUS-FNA.
引言与目的。由胃肠病学家实施的丙泊酚平衡镇静（BPS）在内镜检查中已越来越普遍。关于这种方法在超声内镜引导下细针穿刺活检术（EUS - FNA）期间的安全性研究较少。我们评估了BPS在EUS - FNA中的安全性。材料与方法。2008年2月至2009年12月期间，连续112例转诊至我科进行EUS - FNA的患者接受了BPS镇静。由另一位胃肠病学家给药并监测患者。结果。所有112例患者（62例男性，平均年龄58.35岁）均完成了检查。咪达唑仑和丙泊酚的平均剂量分别为2.1毫克（范围1 - 4毫克）和350毫克（范围180 - 400毫克）。所有患者均接受了平均流量为4升/分钟（范围2 - 6升/分钟）的氧气。术后平均恢复时间为25分钟（范围18 - 45分钟）。所有操作过程中均未记录到与镇静相关的严重并发症。所有患者的血氧饱和度从未降至低于85%。术中及术后收缩压从未降至低于100毫米汞柱。结论。根据我们的经验，由非麻醉医生实施的BPS为接受EUS - FNA的患者提供了安全且成功的镇静。
