出芽酵母的酸性磷酸酶作为转录调控研究的首选模型。
Acid phosphatases of budding yeast as a model of choice for transcription regulation research.
作者信息
Sambuk Elena V, Fizikova Anastasia Yu, Savinov Vladimir A, Padkina Marina V
机构信息
Genetics and Breeding Department, Biology and Soil Sciences Faculty, Saint Petersburg State University, Universitetskaya emb. 7-9, Saint Petersburg 199034, Russia.
出版信息
Enzyme Res. 2011;2011:356093. doi: 10.4061/2011/356093. Epub 2011 Jul 10.
Acid phosphatases of budding yeast have been studied for more than forty years. This paper covers biochemical characteristics of acid phosphatases and different aspects in expression regulation of eukaryotic genes, which were researched using acid phosphatases model. A special focus is devoted to cyclin-dependent kinase Pho85p, a negative transcriptional regulator, and its role in maintaining mitochondrial genome stability and to pleiotropic effects of pho85 mutations.
对出芽酵母的酸性磷酸酶的研究已有四十多年。本文涵盖了酸性磷酸酶的生化特性以及利用酸性磷酸酶模型对真核基因表达调控不同方面的研究。特别关注细胞周期蛋白依赖性激酶Pho85p，一种负转录调节因子，及其在维持线粒体基因组稳定性中的作用，以及pho85突变的多效性效应。
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