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出芽酵母的酸性磷酸酶作为转录调控研究的首选模型。

Acid phosphatases of budding yeast as a model of choice for transcription regulation research.

作者信息

Sambuk Elena V, Fizikova Anastasia Yu, Savinov Vladimir A, Padkina Marina V

机构信息

Genetics and Breeding Department, Biology and Soil Sciences Faculty, Saint Petersburg State University, Universitetskaya emb. 7-9, Saint Petersburg 199034, Russia.

出版信息

Enzyme Res. 2011;2011:356093. doi: 10.4061/2011/356093. Epub 2011 Jul 10.

DOI:10.4061/2011/356093
PMID:21785706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3137970/
Abstract

Acid phosphatases of budding yeast have been studied for more than forty years. This paper covers biochemical characteristics of acid phosphatases and different aspects in expression regulation of eukaryotic genes, which were researched using acid phosphatases model. A special focus is devoted to cyclin-dependent kinase Pho85p, a negative transcriptional regulator, and its role in maintaining mitochondrial genome stability and to pleiotropic effects of pho85 mutations.

摘要

对出芽酵母的酸性磷酸酶的研究已有四十多年。本文涵盖了酸性磷酸酶的生化特性以及利用酸性磷酸酶模型对真核基因表达调控不同方面的研究。特别关注细胞周期蛋白依赖性激酶Pho85p，一种负转录调节因子，及其在维持线粒体基因组稳定性中的作用，以及pho85突变的多效性效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa3/3137970/0d9a5992981c/ER2011-356093.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa3/3137970/aa4e513c48cc/ER2011-356093.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa3/3137970/202b211c145e/ER2011-356093.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa3/3137970/8bb6d63fcf91/ER2011-356093.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa3/3137970/0d9a5992981c/ER2011-356093.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa3/3137970/aa4e513c48cc/ER2011-356093.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa3/3137970/202b211c145e/ER2011-356093.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa3/3137970/8bb6d63fcf91/ER2011-356093.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7aa3/3137970/0d9a5992981c/ER2011-356093.004.jpg

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J Gen Appl Microbiol. 2010;56(6):455-64. doi: 10.2323/jgam.56.455.
2
Rewiring of genetic networks in response to DNA damage.遗传网络对 DNA 损伤的响应重编。
Science. 2010 Dec 3;330(6009):1385-9. doi: 10.1126/science.1195618.
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Uptake of selenite by Saccharomyces cerevisiae involves the high and low affinity orthophosphate transporters.
植物酸性磷酸酶的多面性：纯化、生化特性及应用。
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2282379. doi: 10.1080/14756366.2023.2282379. Epub 2023 Nov 20.
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Comprehensive and quantitative analysis of G1 cyclins. A tool for studying the cell cycle.全面定量分析 G1 周期蛋白。研究细胞周期的工具。
PLoS One. 2019 Jun 25;14(6):e0218531. doi: 10.1371/journal.pone.0218531. eCollection 2019.
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J Food Sci Technol. 2018 Jan;55(1):313-320. doi: 10.1007/s13197-017-2941-9. Epub 2017 Oct 23.
酿酒酵母对亚硒酸盐的摄取涉及高亲和性和低亲和性的正磷酸盐转运蛋白。
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