Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der TU München, Ismaninger Str. 22, 81675, München, Germany.
Eur Arch Psychiatry Clin Neurosci. 2012 Feb;262(1):69-77. doi: 10.1007/s00406-011-0226-2. Epub 2011 Jul 24.
Alzheimer's disease (AD) and mild cognitive impairment (MCI), the transitional clinical stage between cognition in normal aging and dementia, have been linked to abnormalities in brain perfusion. Pulsed arterial spin labeling (PASL) is a magnetic resonance imaging (MRI) technique for evaluating brain perfusion. The present study aimed to determine regional perfusion abnormalities in 19 patients with mild dementia in AD and 24 patients with MCI as compared to 24 cognitively healthy elderly controls using PASL. In line with nuclear imaging methods, lower perfusion in patients with MCI and AD was found mainly in the parietal lobe, but also in angular and middle temporal areas as well as in the left middle occipital lobe and precuneus. Our data imply that PASL may be a valuable instrument for investigating perfusion changes in the transition from normal aging to dementia and indicate that it might become an alternative to nuclear imaging techniques in AD diagnostics.
阿尔茨海默病（AD）和轻度认知障碍（MCI）是认知正常老化和痴呆之间的过渡临床阶段，与脑灌注异常有关。脉冲动脉自旋标记（PASL）是一种评估脑灌注的磁共振成像（MRI）技术。本研究旨在使用 PASL 确定 19 名轻度 AD 痴呆患者、24 名 MCI 患者与 24 名认知健康老年人对照组之间的区域灌注异常。与核成像方法一致，MCI 和 AD 患者的灌注较低主要出现在顶叶，但也出现在角回和颞中回以及左中枕叶和楔前叶。我们的数据表明，PASL 可能是研究从正常老化到痴呆过渡过程中灌注变化的有价值的工具，并表明它可能成为 AD 诊断中核成像技术的替代方法。
