L-2-氧代噻唑烷-4-羧酸对大鼠血浆中与年龄和热暴露相关的氧化还原变化的影响。
L-2-oxothiazolidine-4-carboxylate influence on age- and heat exposure-dependent redox changes in rat's blood plasma.
机构信息
Faculty of Natural Sciences and Mathematics, Institute of Biology, Ss, Cyril and Methodius University, Skopje 1000, Macedonia.
出版信息
J Physiol Sci. 2011 Sep;61(5):437-42. doi: 10.1007/s12576-011-0165-8. Epub 2011 Jul 24.
In the present study, we investigated both the age- and heat exposure-related redox changes of blood plasma by analyzing GSH, thiol status and carbonyl groups. Our results clearly indicated that the plasma redox balance shifted toward oxidation during both aging and acute heat exposure. To further confirm this age- and heat exposure-related redox shift, we quantified the changes in thiol content. The total thiol level was found to be significantly decreased in the aged group. A similar pattern can be explained by low levels of serum GSH in old rats compared to young rats. The significance of the present study are the data showing increased oxidative stress in plasma during aging, attributed to a decrease in major antioxidant components in serum. OTC treatment, in relation to C=O regarded as a marker of oxidative damage was probably much more effective in increasing of GSH synthesis than in prevention of protein oxidation.
在本研究中，我们通过分析 GSH、巯基状态和羰基来研究与年龄和热暴露相关的血浆氧化还原变化。我们的结果清楚地表明，在衰老和急性热暴露过程中，血浆氧化还原平衡向氧化方向转移。为了进一步证实这种与年龄和热暴露相关的氧化还原转变，我们定量了巯基含量的变化。结果发现，衰老组的总巯基水平显著降低。这种相似的模式可以用老年大鼠血清 GSH 水平较低来解释。本研究的意义在于，数据显示衰老过程中血浆氧化应激增加，这归因于血清中主要抗氧化成分的减少。与 C=O 相关的 OTC 治疗，被认为是氧化损伤的标志物，可能在增加 GSH 合成方面比在预防蛋白质氧化方面更为有效。
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