Shen Yang-Mei, Arbman Gunnar, Olsson Birgit, Sun Xiao-Feng
Division of Oncology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping University, Linköping - Sweden and Department of Pathology, West China Second University Hospital, SiChuan University, Chengdu - China.
Int J Biol Markers. 2011 Jul-Sep;26(3):166-72. doi: 10.5301/JBM.2011.8550. Epub 2011 Jul 22.
To investigate the expression of glucose transporter 1 (GLUT1) in colorectal cancer (CRC) and its relationship to clinicopathological variables.
The expression of GLUT1 in 163 primary tumors together with the corresponding normal mucosa, and 36 liver metastases was examined using real-time PCR.
The mean value of GLUT1 was higher in primary tumors (50.390 ± 68.648) than in the corresponding normal mucosa (20.437 ± 28.703, p<0.0001), while there was no significant difference in GLUT1 expression between CRC and liver metastasis (50.390 ± 68.648 vs 52.277 ± 52.482, p=0.190). In CRCs, GLUT1 expression was higher in poorly differentiated than in well and moderately differentiated tumors (p=0.022), and higher in stage III + IV than in stage I + II tumors (p=0.035). The patients with high-expressed GLUT1 had a worse prognosis than those with low-expressed GLUT1 independently of gender, age, tumor site, stage and differentiation (p=0.026, RR 2.737, 95% CI 1.126-6.651) in stage I-III CRCs. In liver metastasis, GLUT1 expression was higher in larger tumors than in smaller ones (p=0.025).
Overexpression of GLUT1 in stage I-III CRCs was independently associated with poor prognosis.
探讨葡萄糖转运蛋白1（GLUT1）在结直肠癌（CRC）中的表达及其与临床病理变量的关系。
采用实时聚合酶链反应检测163例原发性肿瘤及其相应正常黏膜组织以及36例肝转移灶中GLUT1的表达。
原发性肿瘤中GLUT1的平均值（50.390±68.648）高于相应正常黏膜组织（20.437±28.703，p<0.0001），而CRC与肝转移灶之间GLUT-1表达无显著差异（50.390±68.⁃648 vs 52.277±52.482，p=0.190）。在CRCs中，低分化肿瘤中GLUT1的表达高于高分化和中分化肿瘤（p=0.022），III+IV期肿瘤中GLUT1的表达高于I+II期肿瘤（p=0.035）。在I-III期CRCs中，GLUT1高表达患者的预后比低表达患者差，与性别、年龄、肿瘤部位、分期和分化无关（p=0.026，RR 2.737，95%CI 1.126-6.651）。在肝转移灶中，较大肿瘤中GLUT1的表达高于较小肿瘤（p=0.025）。
I-III期CRCs中GLUT1的过表达与预后不良独立相关。
