非小细胞肺癌中全身炎症标志物、葡萄糖转运蛋白1（GLUT1）表达与最大18F-氟脱氧葡萄糖摄取之间的关系及其预后意义
Relationship between Systemic Inflammatory Markers, GLUT1 Expression, and Maximum 18F-Fluorodeoxyglucose Uptake in Non-Small Cell Lung Carcinoma and Their Prognostic Significance.
作者信息
Park Sonya Youngju, Cho Deog-Gon, Shim Byoung-Yong, Cho Uiju
机构信息
Department of Nuclear Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Department of Thoracic Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
出版信息
Diagnostics (Basel). 2023 Mar 7;13(6):1013. doi: 10.3390/diagnostics13061013.
BACKGROUND
Factors involved in inflammation and cancer interact in various ways with each other, and biomarkers of systemic inflammation may have a prognostic value in cancer. Glucose transporter 1 (GLUT1) plays a pivotal role in glucose transport and metabolism and it is aberrantly expressed in various cancer types. We evaluated the differential expression of GLUT1, along with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in non-small-cell lung cancer (NSCLC), and then analyzed their prognostic significance.
METHODS
A total of 163 patients with resectable NSCLC were included in this study. Tumor sections were immunohistochemically stained for GLUT1 and GLUT3. Maximum standardized uptake value (SUV) was measured by preoperative FDG-PET, and neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR) were derived from pretreatment blood count.
RESULTS
GLUT1 and GLUT3 was positively expressed in 74.8% and 6.1% of the NSCLC tissues, respectively. GLUT1 expression was significantly correlated with squamous cell carcinoma histology, poor differentiation, high pathologic stage, old age, male, smoking, and high SUV (>7) (all < 0.05). The squamous cell carcinoma and smoker group also showed significantly higher SUV (both < 0.001). Systemic inflammation markers, including NLR, PLR, and LMR, were positively correlated with high SUV (all < 0.05). High GLUT1 expression, high SUV, high NLR, and low LMR, were significantly associated with poor overall survival in patients with NSCLC. However, in the multivariate survival analysis, LMR was an independent prognostic factor overall (HR 1.86, 95% CI 1.05-3.3) and for the stage I/II cohort (HR 2.3, 95% CI 1.24-4.3) (all < 0.05).
CONCLUSIONS
Systemic inflammatory markers-NLR, PLR, and LMR are strongly correlated with the SUV and are indicators of aggressive tumor behavior. Specifically, LMR is a promising prognostic biomarker in NSCLC patients.
背景
炎症和癌症相关因素相互之间存在多种方式的相互作用，全身炎症生物标志物可能对癌症具有预后价值。葡萄糖转运蛋白1（GLUT1）在葡萄糖转运和代谢中起关键作用，并且在多种癌症类型中异常表达。我们评估了非小细胞肺癌（NSCLC）中GLUT1的差异表达以及18F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）情况，然后分析它们的预后意义。
方法
本研究共纳入163例可切除的NSCLC患者。肿瘤切片进行GLUT1和GLUT3免疫组织化学染色。术前通过FDG-PET测量最大标准化摄取值（SUV），中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及淋巴细胞与单核细胞比值（LMR）来自预处理血常规。
结果
GLUT1和GLUT3在NSCLC组织中的阳性表达率分别为74.8%和6.1%。GLUT1表达与鳞状细胞癌组织学类型、低分化、高病理分期、老年、男性、吸烟以及高SUV（>7）显著相关（均P<0.05）。鳞状细胞癌组和吸烟组的SUV也显著更高（均P<0.001）。全身炎症标志物，包括NLR、PLR和LMR，与高SUV呈正相关（均P<0.05）。高GLUT1表达、高SUV、高NLR和低LMR与NSCLC患者的总生存期差显著相关。然而，在多因素生存分析中，LMR总体上是一个独立的预后因素（风险比1.86，95%置信区间1.05-3.3），对于I/II期队列也是如此（风险比2.3，95%置信区间1.24-4.3）（均P<0.05）。
结论
全身炎症标志物——NLR、PLR和LMR与SUV密切相关，是侵袭性肿瘤行为的指标。具体而言，LMR是NSCLC患者有前景的预后生物标志物。
Zotero 插件