Department of Medical Biochemistry, Ministry of Health Sivas Numune Hospital, Sivas, Turkey.
J Clin Lab Anal. 2011;25(4):289-95. doi: 10.1002/jcla.20471.
Psoriasis is a chronic immune-mediated inflammatory skin disease associated with metabolic syndrome, which is made up of a cluster of disorders, including obesity, diabetes mellitus, dyslipidemia, and cardiovascular disease. The aim of this study was to investigate serum paraoxonase-1 activities and oxidative status parameters in patients with plaque-type psoriasis with or without metabolic syndrome.
In this study, patients with plaque-type psoriasis with (n=25) or without (n=27) metabolic syndrome, according to the criteria of the International Diabetes Federation (IDF), were matched for age and sex to an equally sized control group (n=25).
In patients without metabolic syndrome, serum paraoxonase and arylesterase activities showed mean decreases of 29 and 6%, respectively, whereas in patients with metabolic syndrome, the mean decreases in the enzymes' activities were 35 and 11%, respectively, compared with those in the control group. Serum total antioxidant capacity and total oxidant status were not statistically significant in any of the three groups. Multiple linear regression analysis revealed that HDL cholesterol and log-transformed triglyceride were independent variables for serum arylesterase activity and that fasting glucose and diastolic blood pressure were independent variables for serum paraoxonase activity.
These results suggest that according to the criteria of the IDF, the significant decrease observed in serum paraoxonase activity was independent of the metabolic syndrome in patients with mild-to-moderate plaque-type psoriasis, whereas the significant decrease in serum arylesterase activity was associated with the metabolic syndrome.
银屑病是一种与代谢综合征相关的慢性免疫介导的炎症性皮肤病，代谢综合征由一系列疾病组成，包括肥胖症、糖尿病、血脂异常和心血管疾病。本研究旨在探讨斑块状银屑病患者伴或不伴代谢综合征时血清对氧磷酶-1 活性和氧化状态参数的变化。
本研究中，根据国际糖尿病联合会（IDF）的标准，将 25 例伴代谢综合征的斑块状银屑病患者（观察组）和 27 例无代谢综合征的斑块状银屑病患者（对照组）按年龄和性别与 25 例年龄和性别相匹配的健康人（对照组）相匹配。
在无代谢综合征的患者中，血清对氧磷酶和芳基酯酶活性分别平均下降 29%和 6%，而在有代谢综合征的患者中，与对照组相比，两种酶的活性分别平均下降 35%和 11%。三组患者的血清总抗氧化能力和总氧化状态均无统计学差异。多元线性回归分析显示，高密度脂蛋白胆固醇和对数转换的甘油三酯是血清芳基酯酶活性的独立变量，空腹血糖和舒张压是血清对氧磷酶活性的独立变量。
根据 IDF 的标准，在轻中度斑块状银屑病患者中，观察到的血清对氧磷酶活性的显著下降与代谢综合征无关，而血清芳基酯酶活性的显著下降与代谢综合征有关。
