从乳糜泻动物模型中获得的重要经验。
Important lessons derived from animal models of celiac disease.
机构信息
Department of Immunology, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
出版信息
Int Rev Immunol. 2011 Aug;30(4):197-206. doi: 10.3109/08830185.2011.598978.
Abstract
Several animal models have been recently developed to recapitulate various components of the complex process that is celiac disease. In addition to the increasing diversity of murine models there are now monkey models of celiac disease. Mouse strains and protocols have been developed that are now just beginning to address the complex interactions among the innate and adaptive immune responses to gluten, as well as gluten-dependent autoimmunity in celiac disease. The most important conclusion that these models have provided us with so far is that while all three components (innate gluten sensitivity, adaptive gluten sensitivity, and autoimmunity) are independent phenomena, all are necessary for celiac disease to develop.
摘要
最近已经开发了几种动物模型来重现乳糜泻这一复杂过程的各个组成部分。除了越来越多样化的鼠模型外，现在也有乳糜泻的猴模型。现在已经开发出了针对对 gluten 的先天和适应性免疫反应以及乳糜泻中 gluten 依赖性自身免疫之间的复杂相互作用的小鼠品系和方案。到目前为止，这些模型给我们提供的最重要的结论是，虽然所有三个组成部分（先天对 gluten 的敏感性、适应性对 gluten 的敏感性和自身免疫）都是独立的现象，但对于乳糜泻的发展都是必要的。
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