Elsbach P, Weiss J
Department of Medicine, New York University School of Medicine, New York, USA.
Infect Agents Dis. 1995 Jun;4(2):102-9.
The bactericidal/permeability-increasing protein (BPI), a potent cytotoxin specific for Gram-negative bacteria and an endotoxin-neutralizing agent, is a major component of the antimicrobial arsenal of mammalian polymorphonuclear leukocytes. The antibacterial and endotoxin-neutralizing activities of the N-terminal portion (approximately 25 kDa) of BPI are at least equal to those of the holoprotein (approximately 50 kDa). Recombinant N-terminal fragments of BPI are antibacterial and inhibit host cell responses to endotoxin in whole blood ex vivo and in animal experiments. BPI administered to both animals and man is apparently nontoxic and nonimmunogenic and acts synergistically with some antibiotics. Thus, the prospects for the therapeutic use of bioactive BPI fragments in serious Gram-negative bacterial infections are highly encouraging.
杀菌/通透性增加蛋白（BPI）是一种对革兰氏阴性菌具有特异性的强效细胞毒素和内毒素中和剂，是哺乳动物多形核白细胞抗菌武器库的主要成分。BPI N端部分（约25 kDa）的抗菌和内毒素中和活性至少与全蛋白（约50 kDa）相当。BPI的重组N端片段具有抗菌作用，并能在体外全血和动物实验中抑制宿主细胞对内毒素的反应。给动物和人类使用BPI显然无毒且无免疫原性，并且能与某些抗生素协同作用。因此，生物活性BPI片段在严重革兰氏阴性菌感染治疗中的应用前景非常广阔。
