实验性强力霉素过量对健康犊牛心脏影响的临床评价。
Clinical evaluation of cardiac effects of experimental doxycycline overdosing in healthy calves.
机构信息
Department of Companion Animals and Equids, Equine Clinic, B41. Faculty of Veterinary Medicine, University of Liège, 20, Boulevard de Colonster, Sart Tilman, Liège, Belgium.
出版信息
BMC Vet Res. 2011 Jul 25;7:40. doi: 10.1186/1746-6148-7-40.
BACKGROUND
Cardiac morphologic and functional changes consistent with cardiomyopathy have been reported in field cases of calves with accidental doxycycline overdosing. The purpose of this study was to evaluate clinically the cardiac effects of an experimentally-induced doxycycline overdosing in healthy calves. Twelve 2 months-old healthy Belgian Blue calves were studied. Six of them (group 1) received the normal dose (5 mg/kg, BID) and the six others (group 2) received five times the normal dose (25 mg/kg, BID) of oral doxycycline for five consecutive days (D1 to D5). Each calf was clinically examined daily. Measurement of serum AST, CK, Iso-CKs and LDH activities and an echocardiographic examination were performed before (D0) and one day after (D6) the last doxycycline administration. An ECG tracing was recorded at D0, D4, and D6.
RESULTS
In both groups, no clinical, blood, echocardiographic or electrocardiographic changes suggestive of a cardiomyopathy were observed. Only a decreased appetite was observed in the calves of the group 2 between D3 and D6.
CONCLUSIONS
This trial failed to reproduce cardiac changes reported in accidental doxycycline-poisoning in calves, suggesting that high doses of doxycycline may not be the only etiologic factor of the cardiomyopathy reported in the field cases.
背景
在偶然过量服用强力霉素的犊牛的田间病例中，已经报道了与心肌病一致的心脏形态和功能变化。本研究的目的是评估健康犊牛中实验性强力霉素过量引起的心脏效应。
方法
研究了 12 头 2 月龄健康的比利时蓝牛。其中 6 头（第 1 组）接受了正常剂量（5mg/kg，BID），另外 6 头（第 2 组）连续 5 天接受了正常剂量的 5 倍（25mg/kg，BID）的口服强力霉素（D1 至 D5）。每头犊牛每天进行临床检查。在最后一次强力霉素给药前（D0）和给药后 1 天（D6）测量血清 AST、CK、同工酶 CK 和 LDH 活性，并进行超声心动图检查。在 D0、D4 和 D6 记录心电图描记。
结果
两组均未观察到提示心肌病的临床、血液、超声心动图或心电图变化。仅第 2 组的犊牛在 D3 至 D6 之间出现食欲下降。
结论
本试验未能重现偶然强力霉素中毒的犊牛中报道的心脏变化，这表明高剂量强力霉素可能不是田间病例中报道的心肌病的唯一病因。
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