Toxicokinetics Section and Petroleum Toxicology Division, Indian Institute of Toxicology Research (Formerly: Industrial Toxicology Research Centre) [Council of Scientific and Industrial Research, India], Post Box 80, Mahatma Gandhi Marg, Lucknow 226001, India.
Environ Toxicol Pharmacol. 2010 Jan;29(1):70-8. doi: 10.1016/j.etap.2009.10.003. Epub 2009 Nov 10.
We have examined the effect of both pre- and post-treatment of vitamin E on mercury induced acute toxicity in rats. Mercury (12μmol/kg b.w., single intraperitoneal injection) resulted in oxidative injury and metallothionein mRNA expression together with alterations in tissue histology and accumulation of mercury in the body organs. The ameliorating potential of vitamin E (24μmol/kg b.w., single intraperitoneal injection) was observed in mercury administered rats. Our findings indicate that vitamin E provides complete protection from mercury toxicity in the liver with both pre- and post-treatments. As mercury is nephrotoxic and neurotoxic, it is interesting to note that post-treatment of vitamin E showed more protection in the kidney compared to pre-treatment. In brain tissue, partial protection was observed on oxidative stress parameters. Our results thus suggest that post-treatment with vitamin E could be more beneficial than pre- treatment in mercury intoxication.
我们研究了维生素 E 预处理和后处理对大鼠体内汞诱导的急性毒性的影响。汞（12μmol/kg 体重，单次腹腔注射）导致氧化损伤和金属硫蛋白 mRNA 表达，同时改变组织病理学和体内器官汞的积累。维生素 E（24μmol/kg 体重，单次腹腔注射）对给予汞的大鼠具有改善作用。我们的研究结果表明，维生素 E 对肝脏中的汞毒性具有完全的保护作用，无论是预处理还是后处理。由于汞具有肾毒性和神经毒性，有趣的是，与预处理相比，维生素 E 的后处理在肾脏中显示出更强的保护作用。在脑组织中，氧化应激参数观察到部分保护。因此，我们的结果表明，维生素 E 的后处理可能比预处理在汞中毒中更有益。
