Department of Biochemistry, Yuvaraja's College, University of Mysore, Mysuru, Karnataka, 570005, India.
Department of Basic Science, Biology Unit Deanship of Preparatory Year and Supporting studies, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 34212, Saudi Arabia.
Mol Biol Rep. 2019 Dec;46(6):6171-6179. doi: 10.1007/s11033-019-05052-7. Epub 2019 Sep 6.
The toxicity of heavy metals such as mercury (Hg) in humans and animals is well documented. The kidney is the primary deposition site of inorganic-Hg and target organ of its toxicity. The present study investigated the protective efficacy of flaxseed lignan-Secoisolariciresinol diglucoside (SDG) on nephrotoxicity induced by mercuric chloride (HgCl). Rats were intraperitoneally injected with HgCl (2 mg/kg/day) and renal toxicity was induced. Subcutaneous administration of rats with SDG (5 mg/kg/day) as a pre-treatment caused a significant reversal of HgCl induced increase in blood urea, creatinine, glutathione s-transferase and catalase (CAT). On the other hand, administration of SDG with HgCl restored normal levels of albumin and superoxide dismutase (SOD). Histological examination of kidneys confirmed that pre-treatment of SDG before HgCl administration significantly reduced its pathological effects. Thus, the results of the present investigation suggest that SDG can significantly reduce renal damage, serum and tissue biochemical profiles caused by HgCl induced nephrotoxicity. Hence, SDG may be recommended for clinical trials in the treatment of kidney disorders caused by exposure to Hg.
重金属如汞（Hg）对人类和动物的毒性已有充分的文献记载。肾脏是无机汞的主要沉积部位，也是其毒性的靶器官。本研究探讨了亚麻籽木脂素-松脂素二葡萄糖苷（SDG）对氯化汞（HgCl）引起的肾毒性的保护作用。大鼠腹腔注射 HgCl（2mg/kg/天）诱导肾毒性。SDG（5mg/kg/天）作为预处理皮下给药可显著逆转 HgCl 诱导的血尿素、肌酐、谷胱甘肽 s-转移酶和过氧化氢酶（CAT）升高。另一方面，SDG 与 HgCl 联合给药可使白蛋白和超氧化物歧化酶（SOD）恢复正常水平。肾脏组织学检查证实，SDG 在 HgCl 给药前预处理可显著减轻其病理作用。因此，本研究结果表明，SDG 可显著减轻 HgCl 诱导的肾毒性引起的肾脏损伤、血清和组织生化谱变化。因此，SDG 可能被推荐用于临床试验，以治疗因接触 Hg 引起的肾脏疾病。
