School of Environmental Science and Public Health, Wenzhou Medical College, Wenzhou 325035, China.
Environ Toxicol Pharmacol. 2011 Jul;32(1):35-9. doi: 10.1016/j.etap.2011.03.004. Epub 2011 Mar 15.
In this study, the oxidative stress induced by deca-polybromodiphenyl ether (BDE-209) was investigated in livers of Carassius auratus. Six groups of fish were exposed to blank and 0, 0.004, 0.04, 0.4, 4 μM BDE-209 (in 0.1% DMSO) for 1, 4, 7, 10, 13 d, respectively. The following oxidative stress markers were analyzed: reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidases (GPx) and glutathione S-transferases (GSTs). No significant difference was observed in the content of GSH over the whole period of exposure (p > 0.05). Increases in hepatic GR and GPx activities were in concomitant with the decrease in GST activity. GR activity was induced after 1 d exposure, while GPx activity reached maximum at 4 d after exposure to 0.04 μM BDE-209 and GST activity was significantly inhibited at 7-13 d in all the treatment groups (0.004-4 μM group).
在这项研究中，研究了十溴联苯醚（BDE-209）对鲫鱼肝脏的氧化应激。将六组鱼分别暴露于空白组和 0、0.004、0.04、0.4、4 μM BDE-209（溶于 0.1% DMSO）中，暴露时间分别为 1、4、7、10、13 天。分析了以下氧化应激标志物：还原型谷胱甘肽（GSH）、谷胱甘肽还原酶（GR）、谷胱甘肽过氧化物酶（GPx）和谷胱甘肽 S-转移酶（GSTs）。在整个暴露期间，GSH 的含量没有明显差异（p＞0.05）。肝 GR 和 GPx 活性的增加与 GST 活性的降低同时发生。GR 活性在暴露 1 天后被诱导，而 GPx 活性在暴露于 0.04 μM BDE-209 4 天后达到最大值，并且 GST 活性在所有处理组的 7-13 天（0.004-4 μM 组）均受到显著抑制。
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