Department of Rehabilitation Medicine, Wakayama Medical University, Wakayama, Japan.
Spinal Cord. 2011 Dec;49(12):1182-7. doi: 10.1038/sc.2011.74. Epub 2011 Jul 26.
Non-randomized study.
Previous studies indicated that at least 2-h leg exercise at more than 60% maximum oxygen consumption (VO(2)max) increased plasma interleukin (IL)-6 in able-bodied (AB) subjects. The purpose of the present study was to compare IL-6 response to arm exercise in AB subjects and persons with spinal cord injury (SCI).
Wakayama Medical University in Japan.
Six subjects with SCI between T6 and T10 and seven AB subjects performed 2-h arm crank ergometer exercise at 60%VO(2)max. Plasma catecholamines, IL-6, tumor necrosis factor (TNF)-α and high-sensitivity C-reactive protein (hsCRP) were measured before exercise, 60-min exercise, immediately and 2 h after the completion of exercise.
Arm exercise increased myoglobin and plasma IL-6 levels in SCI and AB (P<0.01), but there were no differences in them between the two groups throughout the study. Plasma levels creatine kinase, lactate dehydrogenase, TNF-α and hsCRP did not change throughout the study in both groups.
These findings suggest neither significant muscle damage nor inflammatory response during exercise. The increase in plasma IL-6 in SCI was not unexpected, confirming that moderate intensity and relatively long-arm exercise is safe and beneficial for SCI subjects with regard to IL-6 excretion, as in AB subjects.
非随机研究。
先前的研究表明，至少 2 小时、超过 60%最大摄氧量（VO2max）的腿部运动可增加健康受试者（AB）的血浆白细胞介素（IL）-6。本研究的目的是比较 AB 受试者和脊髓损伤（SCI）受试者手臂运动对 IL-6 的反应。
日本和歌山医科大学。
6 名 T6 至 T10 节段 SCI 受试者和 7 名 AB 受试者以 60%VO2max 进行 2 小时手臂曲柄测力计运动。在运动前、运动 60 分钟、运动结束后即刻和 2 小时测量血浆儿茶酚胺、IL-6、肿瘤坏死因子（TNF）-α和高敏 C 反应蛋白（hsCRP）。
手臂运动增加了 SCI 和 AB 受试者的肌红蛋白和血浆 IL-6 水平（P<0.01），但在整个研究过程中两组之间没有差异。两组在整个研究过程中，血浆肌酸激酶、乳酸脱氢酶、TNF-α和 hsCRP 均未发生变化。
这些发现表明运动过程中没有明显的肌肉损伤或炎症反应。SCI 受试者血浆 IL-6 增加并不出人意料，证实了中等强度和相对较长时间的手臂运动对 SCI 受试者是安全且有益的，可促进 IL-6 排泄，与 AB 受试者相同。
