植物泛素-蛋白酶体途径及其在赤霉素信号转导中的作用。
Plant ubiquitin-proteasome pathway and its role in gibberellin signaling.
机构信息
Peking-Yale Joint Center for Plant Molecular Genetics and Agro-Biotechnology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China.
出版信息
Cell Res. 2011 Sep;21(9):1286-94. doi: 10.1038/cr.2011.118. Epub 2011 Jul 26.
Abstract
The ubiquitin-proteasome system (UPS) in plants, like in other eukaryotes, targets numerous intracellular regulators and thus modulates almost every aspect of growth and development. The well-known and best-characterized outcome of ubiquitination is mediating target protein degradation via the 26S proteasome, which represents the major selective protein degradation pathway conserved among eukaryotes. In this review, we will discuss the molecular composition, regulation and function of plant UPS, with a major focus on how DELLA protein degradation acts as a key in gibberellin signal transduction and its implication in the regulation of plant growth.
摘要
植物中的泛素-蛋白酶体系统 (UPS) 与其他真核生物一样，靶向许多细胞内调节剂，从而调节生长和发育的几乎各个方面。泛素化的众所周知且研究得最好的结果是通过 26S 蛋白酶体介导靶蛋白降解，26S 蛋白酶体是真核生物中保守的主要选择性蛋白降解途径。在这篇综述中，我们将讨论植物 UPS 的分子组成、调控和功能，主要集中在 DELLA 蛋白降解如何作为赤霉素信号转导的关键以及其对植物生长调控的影响。
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