Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University School of Medicine and the Monroe Carell, Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA,
Curr Infect Dis Rep. 2011 Oct;13(5):451-60. doi: 10.1007/s11908-011-0202-z.
Acute hematogenous osteomyelitis is a common disease that affects previously healthy children of all age groups. Despite its importance, there are limited data in the current literature to guide many aspects of the diagnosis and therapy of this infection. Over the last decade, our understanding of the etiology of this infection has changed, with increased recognition of Kingella kingae and the dramatic increase in community-associated Methicillin-resistant Staphylococcus aureus (CA-MRSA) infections. There is a need for the optimization of diagnostic strategies, such as MRI and serum inflammatory markers. Several recent studies have examined treatment strategies, including a rapid transition to oral antimicrobial therapy and a shortened overall course of therapy. Many new therapeutic options are on the horizon that will likely impact the management of this and other childhood bacterial infections. This review summarizes recent investigations into the optimal diagnosis and management of acute hematogenous osteomyelitis in children.
急性血源性骨髓炎是一种常见疾病，影响所有年龄段的健康儿童。尽管它很重要，但目前的文献中关于这种感染的诊断和治疗的许多方面的数据有限。在过去的十年中，我们对这种感染的病因的理解已经发生了变化，越来越多的人认识到金氏金氏菌和社区相关耐甲氧西林金黄色葡萄球菌（CA-MRSA）感染的急剧增加。需要优化诊断策略，如 MRI 和血清炎症标志物。最近的几项研究检查了治疗策略，包括快速过渡到口服抗菌治疗和缩短整体治疗过程。许多新的治疗选择即将出现，这可能会影响这种和其他儿童细菌性感染的治疗。本综述总结了最近对儿童急性血源性骨髓炎的最佳诊断和治疗的研究。
