Department of Nutrition and Food Chemistry, Faculty of Pharmacy, University of Granada, 18071, Granada, Spain.
Biol Trace Elem Res. 2011 Dec;144(1-3):496-503. doi: 10.1007/s12011-011-9152-4. Epub 2011 Jul 26.
In the present study, the first objective was to follow up serum selenium (Se) concentrations in 117 hemodialysis patients (HPs) during a 2-year longitudinal study, relating concentrations to biochemical indexes (n = 6; namely lipoprotein profile, uric acid, and total protein levels). It was also evaluated whether the disease is associated with an enhanced cardiovascular risk. A healthy control group (n = 50) was also studied. Mean serum Se levels were significantly lower in HPs than in the controls (p = 0.002); mean levels significantly increased from the first to third blood sampling (p < 0.001). HPs showed a marked dyslipidemia, with a significant reduction in total cholesterol, low-density lipoprotein, and high-density lipoprotein cholesterol levels and a significant increase in triglyceride levels (p < 0.001). HPs showed a marked hyperuricemia (p < 0.001). Serum selenium levels in HPs were correlated negatively with uric acid levels (inflammation biomarker; p < 0.01). In HPs, serum Se levels are reduced due to their disease (chronic renal failure). Serum Se levels rose until the third blood sampling. The marked dyslipidemia and hyperuricemia found in HPs and the negative correlation between the serum Se and uric acid levels in these patients could imply an enhanced cardiovascular risk.
在本研究中，第一个目的是在一项为期 2 年的纵向研究中，跟踪 117 名血液透析患者（HPs）的血清硒（Se）浓度，将浓度与生化指标相关联（n=6；即脂蛋白谱、尿酸和总蛋白水平）。还评估了该疾病是否与心血管风险增加有关。还研究了一个健康对照组（n=50）。与对照组相比，HPs 的血清 Se 水平明显较低（p=0.002）；从第一次采血到第三次采血，平均水平显著升高（p<0.001）。HPs 表现出明显的血脂异常，总胆固醇、低密度脂蛋白和高密度脂蛋白胆固醇水平显著降低，甘油三酯水平显著升高（p<0.001）。HPs 表现出明显的高尿酸血症（p<0.001）。HPs 中的血清 Se 水平与尿酸水平呈负相关（炎症生物标志物；p<0.01）。由于慢性肾衰竭，HPs 中的血清 Se 水平降低。血清 Se 水平在第三次采血前升高。在 HPs 中发现的明显血脂异常和高尿酸血症，以及这些患者血清 Se 与尿酸水平之间的负相关，可能意味着心血管风险增加。
