Ansari Muhammad Rafique, Maheshwari Narinder, Shaikh Muzaffar A, Laghari Muhammad Shahzad, Lal Kumar, Ahmed Kamran
Department of Nephro-Urology, Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro, Pakistan.
Saudi J Kidney Dis Transpl. 2012 Jan;23(1):21-5.
This study was performed to determine the correlation between serum magnesium (Mg) and dyslipidemia in patients on maintenance hemodialysis (MHD). This hospital-based cross-sectional observational study was conducted at the Department of Nephro-Urology, Liaquat University Hospital, Hyderabad, Pakistan, from April 2008 to June 2008. Fifty patients with end-stage kidney disease on MHD treatment (33 males and 17 females) were studied. The mean duration on HD was 7.58 ± 2.05 years, with frequency being two to three sessions/week, and each session lasted for four hours. After obtaining informed written consent, the general information of each patient was recorded on a proforma. After overnight fasting, blood samples was drawn from the arterio-venous fistula for lipid profile, lipoprotein, serum Mg, serum creatinine, blood urea, serum calcium and serum phosphorus. Dyslipidemia was defined as presence of total cholesterol (TC), triglyceride (TG) or low-density lipoprotein (LDL) levels more then 95 th percentile for age and gender or high-density lipoprotein (HDL) levels less then 35 mg/dL. Descriptive and inferential statistical analyses were performed using SPSS version 16.0. The mean age of the study patients was 45.68 ± 13.97 years. There was a significant positive correlation between serum Mg and serum lipoprotein-a (LP-a) (r = 0.40, P < 0.007), serum HDL (r = 0.31, P < 0.01) and serum TG (r = 0.35, P < 0.005). There was no significant correlation between serum Mg and serum LDL-c and serum TC. The serum TG and LP-a levels were significantly increased while HDL-c was significantly lower in MHD patients. The serum TC, LDL-c and very low-density lipoprotein-c were not significantly elevated. We conclude that patients with chronic kidney disease undergoing MHD show positive correlation between serum Mg and serum HDL, LP-a and TG. The abnormalities of lipid metabolism, such as hyper-triglyceridemia, elevated LP-a and low HDL-c, could contribute to atherosclerosis and cardiovascular disease in these patients.
本研究旨在确定维持性血液透析（MHD）患者血清镁（Mg）与血脂异常之间的相关性。这项基于医院的横断面观察性研究于2008年4月至2008年6月在巴基斯坦海得拉巴利亚卡特大学医院肾泌尿外科进行。对50例接受MHD治疗的终末期肾病患者（33例男性和17例女性）进行了研究。HD的平均时长为7.58±2.05年，频率为每周两到三次，每次时长为四小时。在获得知情书面同意后，将每位患者的一般信息记录在一份表格上。过夜禁食后，从动静脉瘘抽取血样，检测血脂、脂蛋白、血清镁、血清肌酐、血尿素、血清钙和血清磷。血脂异常定义为总胆固醇（TC）、甘油三酯（TG）或低密度脂蛋白（LDL）水平高于年龄和性别的第95百分位数，或高密度脂蛋白（HDL）水平低于35mg/dL。使用SPSS 16.0版本进行描述性和推断性统计分析。研究患者的平均年龄为45.68±13.97岁。血清镁与血清脂蛋白a（LP-a）（r = 0.40，P < 0.007）、血清HDL（r = 0.31，P < 0.01）和血清TG（r = 0.35，P < 0.005）之间存在显著正相关。血清镁与血清LDL-c和血清TC之间无显著相关性。MHD患者的血清TG和LP-a水平显著升高，而HDL-c显著降低。血清TC、LDL-c和极低密度脂蛋白-c没有显著升高。我们得出结论，接受MHD治疗的慢性肾病患者血清镁与血清HDL、LP-a和TG之间呈正相关。脂质代谢异常，如高甘油三酯血症、LP-a升高和HDL-c降低，可能导致这些患者发生动脉粥样硬化和心血管疾病。
