Josephs L K, Gregg I, Holgate S T
Immunopharmacology group, Medicine I, Southampton General Hospital, UK.
Eur Respir J. 1990 Feb;3(2):220-7.
It is difficult to analyse the relationship between bronchial responsiveness and the severity of asthma since each alone is difficult to assess. Asthma is a heterogeneous condition with many patterns of expression, and clinical methods used to assess its severity have their limitations. Problems also arise in interpreting the results of bronchial provocation tests and methodological differences make comparisons between studies difficult. The findings of both cross-sectional and longitudinal studies have shown a general relationship between the degree of responsiveness and the severity of asthma, but within subjects the relationship is weaker. A greater understanding must await increased knowledge of the mechanisms underlying asthma and the contribution which hyperresponsiveness makes to each of these.
由于单独评估支气管反应性和哮喘严重程度都很困难，因此很难分析它们之间的关系。哮喘是一种具有多种表现形式的异质性疾病，用于评估其严重程度的临床方法存在局限性。在解释支气管激发试验结果时也会出现问题，而且方法学上的差异使得不同研究之间难以进行比较。横断面研究和纵向研究的结果均表明，反应性程度与哮喘严重程度之间存在一般关系，但在个体内部，这种关系较弱。要更深入地理解这一关系，必须等待对哮喘潜在机制以及高反应性在其中所起作用的了解有所增加。
