Chhabra S K, Gaur S N, Khanna A K
Clinical Research Centre, Vallabhbhai Patel Chest Institute, University of Delhi, India.
Chest. 1989 Sep;96(3):596-600. doi: 10.1378/chest.96.3.596.
Measurement of nonspecific bronchial hyperresponsiveness remains largely a research tool in asthma, and its usefulness in the assessment and management of asthma is poorly defined. We studied the relationship of bronchial hyperresponsiveness to the clinical severity of asthma in 54 asthmatic subjects. In order to find out whether measurement of bronchial hyperresponsiveness could be used to predict future symptomatic status and requirements for drugs, ten patients were followed for three months. We found that there was no correlation between the clinical severity of asthma and the degree of bronchial hyperresponsiveness and, also, that the latter could not be used as a prognostic indicator of future symptomatic status and drug requirements. Measurement of nonspecific bronchial hyperresponsiveness, therefore, adds little to the assessment and management of asthma.
非特异性支气管高反应性的测定在很大程度上仍是哮喘研究中的一种工具，其在哮喘评估和管理中的作用尚不明确。我们研究了54例哮喘患者支气管高反应性与哮喘临床严重程度之间的关系。为了弄清楚支气管高反应性的测定是否可用于预测未来的症状状态和药物需求，对10例患者进行了为期3个月的随访。我们发现哮喘的临床严重程度与支气管高反应性程度之间无相关性，而且支气管高反应性也不能作为未来症状状态和药物需求的预后指标。因此，非特异性支气管高反应性的测定对哮喘的评估和管理作用不大。
