Department of Neurological Surgery, Neurological Institute of New York, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA.
J Neurooncol. 2012 Jan;106(2):235-42. doi: 10.1007/s11060-011-0666-6. Epub 2011 Jul 26.
Abnormal signaling through the platelet-derived growth factor receptor (PDGFR) has been proposed as a possible mechanism of spinal cord glioma initiation and progression. However, the extent of PDGFR expression in human spinal cord gliomas remains unknown. In this study we perform immunohistochemical analysis of PDGFRα expression in a series of 33 primary intramedullary spinal cord gliomas of different types and grades. PDGFRα was seen to be expressed in a significant subset of these tumors across all major glioma types including ependymoma, oligodendroglioma, pilocytic astrocytoma, astrocytoma, and glioblastoma. These results support the hypothesis that growth factor signaling through the PDGFR may be important for the development of at least a subset of human spinal cord gliomas. Further studies investigating the prognostic significance of PDGFR expression as well as the role of PDGF signaling on the development of intramedullary spinal cord gliomas are warranted.
血小板衍生生长因子受体（PDGFR）的异常信号转导被认为是脊髓神经胶质瘤发生和进展的一种可能机制。然而，PDGFR 在人脊髓神经胶质瘤中的表达程度尚不清楚。在这项研究中，我们对 33 例不同类型和分级的原发性脊髓内神经胶质瘤进行了 PDGFRα 免疫组化分析。PDGFRα 在包括室管膜瘤、少突胶质细胞瘤、毛细胞型星形细胞瘤、星形细胞瘤和胶质母细胞瘤在内的所有主要神经胶质瘤类型中均有显著表达。这些结果支持这样一种假设，即通过 PDGFR 的生长因子信号转导对于至少一部分人类脊髓神经胶质瘤的发生可能很重要。进一步研究 PDGFR 表达的预后意义以及 PDGF 信号在脊髓内神经胶质瘤发生中的作用是必要的。
