State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
Int J Oral Sci. 2011 Jul;3(3):141-52. doi: 10.4248/IJOS11052.
This article provides an overview of metastases to jaws (MJ), mainly concerning the differences between American and Chinese patients, and exploring the relationship between the primary tumors' prevalence (PTP) and constituent ratio of MJ. Information concerning of 399 MJ cases in 215 papers, including one new case in our hospital, was subjected to statistic analysis. The main clinical features of MJ, such as constituent ratio of PTP and that of MJ, metastatic sites, treatments, and prognosis were summarized. Breast, lung, kidney, prostate and thyroid (in descending order) were the leading primary sites of MJ. Furthermore, the constituent ratio of MJ was found to be correlated with that of PTP in all subjects including American and Chinese subjects in our study. As to metastatic sites in the mandible, a specific "M" shaped pattern appeared regardless of the tumor type or constituent ratios of MJ were in all subjects. Almost all subjects received traditionally palliative treatments, and the prognosis was quite poor. The PTP had a significant impact on the constituent ratio of MJ. However, it was the properties of the microenvironment rather than characteristics or constituent ratios of tumor cells, that decided the metastatic sites in various tumor subjects.
本文概述了发生于颌骨的转移瘤（MJ），主要涉及中美患者的差异，并探讨了原发肿瘤患病率（PTP）与 MJ 构成比之间的关系。对 215 篇文献中的 399 例 MJ 病例资料（包括我院 1 例新病例）进行了统计学分析。总结了 MJ 的主要临床特征，如 PTP 和 MJ 的构成比、转移部位、治疗和预后。在本研究中，包括中美患者在内的所有患者中，乳腺、肺、肾、前列腺和甲状腺（依次递减）是 MJ 的主要原发部位。此外，在本研究的所有患者中，包括美国患者和中国患者，MJ 的构成比与 PTP 的构成比相关。至于下颌骨的转移部位，无论肿瘤类型或 MJ 的构成比如何，均出现了一种特定的“M”形模式。几乎所有患者均接受传统的姑息性治疗，预后较差。PTP 对 MJ 的构成比有显著影响。然而，决定不同肿瘤患者转移部位的是微环境的特性，而非肿瘤细胞的特征或构成比。
