Settheetham-Ishida Wannapa, Yuenyao Pissamai, Natphopsuk Sitakan, Settheetham Dariwan, Ishida Takafumi
Department of Physiology, Khon Kaen University, Khon Kaen, Thailand.
Asian Pac J Cancer Prev. 2011;12(4):963-6.
To identify risk factors other than high risk human papillomavirus infection for the development of cervical cancer, functional polymorphisms of DNA repair genes, XRCC1 Arg399Gln and Arg194Trp and XRCC3 Thr241Met, were studied among Northeastern Thai women. Cases (n=111) were defined as squamous cell cervical cancer and controls (n=118) were recruited from healthy women without cervical abnormalities. The XRCC1 194Trp/Trp genotype significantly increased the risk for cervical cancer (OR=5.52; 95%CI=1.14-26.64; p=0.03). Among the HPV infection negative group, significantly higher risks for cervical cancer were visualized for XRCC1 399Arg/Gln (adjusted OR=3.69; 95%CI=1.04-13.06; p=0.04) and XRCC1 194Arg/Trp (adjusted OR=4.13; 95%CI=1.13-15.12; p=0.03). This study indicates that variant types of DNA repair genes play partial roles in modifying individual susceptibility to cervical cancer. Since cervical cancer is a multi-factorial disease, the contribution of DNA repair enzymes to the development of cervical cancer, if it exists may be concealed by HPV infection.
为了确定除高危型人乳头瘤病毒感染之外的宫颈癌发生风险因素，我们对泰国东北部女性的DNA修复基因XRCC1 Arg399Gln、Arg194Trp以及XRCC3 Thr241Met的功能多态性进行了研究。病例组（n = 111）被定义为宫颈鳞状细胞癌患者，对照组（n = 118）则从无宫颈异常的健康女性中招募。XRCC1 194Trp/Trp基因型显著增加了患宫颈癌的风险（OR = 5.52；95%CI = 1.14 - 26.64；p = 0.03）。在HPV感染阴性组中，XRCC1 399Arg/Gln（校正OR = 3.69；95%CI = 1.04 - 13.06；p = 0.04）和XRCC1 194Arg/Trp（校正OR = 4.13；95%CI = 1.13 - 15.12；p = 0.03）患宫颈癌的风险也显著更高。本研究表明，DNA修复基因的变异类型在改变个体对宫颈癌的易感性方面发挥了部分作用。由于宫颈癌是一种多因素疾病，DNA修复酶对宫颈癌发生的作用（如果存在的话）可能会被HPV感染所掩盖。
