一项关于 XRCC3 rs861539、MTHFR rs1801133、IL-6 rs1800795、IL-12B rs3212227、TNF-α rs1800629 和 TLR9 rs352140 多态性与宫颈癌易感性关联的荟萃分析。
A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma.
机构信息
Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Asian Pac J Cancer Prev. 2021 Nov 1;22(11):3419-3431. doi: 10.31557/APJCP.2021.22.11.3419.
BACKGROUND
In spite of substantial declines in both incidence and mortality rates in the past 50 years, cervical cancer remains one of the leading causes of cancer associated mortality among women globally. We performed this meta-analysis to explore the role of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629 and TLR9 rs352140 polymorphism with susceptibility to cervical carcinoma.
METHODS
The search databases include PubMed, SciELO, MedRxiv, Web of Science, Scopus, Cochrane Library, China National Knowledge Infrastructure, and China Biology Medicine disc up to 30 June 2021. The language is limited to English and Chinese. The comparison between the polymorphisms and cervical cancer was assessed using pooled odds ratio (OR) and 95% confidence interval (CI). The data are statistically analyzed by Comprehensive Meta-Analysis (CMA) 2.0 software.
RESULTS
A total of 59 studies including seven studies with 1,112 cases and 1,233 controls on XRCC3 rs861539, 14 studies with 2,694 cases and 3349 controls MTHFR rs1801133, four studies with 1,121 cases and 1,109 controls on IL-12B rs3212227, seven studies with 1,452 cases and 2,186 controls on IL-6 rs1800795, 20 studies with 4,781 cases and 4909 controls on TNF-α rs1800629, and seven studies with 1743 cases and 2292 controls on TLR9 rs352140 were included. There was a significant association between XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 polymorphisms and an increased risk of cervical carcinoma in overall population. However, the MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms were not associated.
CONCLUSION
The pooled analysis showed that XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 were associated with cervical carcinoma susceptibility, but not MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms.
背景
尽管在过去 50 年中发病率和死亡率都大幅下降，但宫颈癌仍然是全球女性癌症相关死亡的主要原因之一。我们进行了这项荟萃分析，以探讨 XRCC3 rs861539、MTHFR rs1801133、IL-6 rs1800795、IL-12B rs3212227、TNF-α rs1800629 和 TLR9 rs352140 多态性与宫颈癌易感性的关系。
方法
搜索数据库包括 PubMed、SciELO、MedRxiv、Web of Science、Scopus、Cochrane Library、中国国家知识基础设施和中国生物医学光盘，截至 2021 年 6 月 30 日。语言仅限于英语和中文。使用合并优势比（OR）和 95%置信区间（CI）评估多态性与宫颈癌之间的关系。使用 Comprehensive Meta-Analysis（CMA）2.0 软件进行数据分析。
结果
共纳入 59 项研究，其中 7 项研究纳入 1112 例病例和 1233 例对照的 XRCC3 rs861539，14 项研究纳入 2694 例病例和 3349 例对照的 MTHFR rs1801133，4 项研究纳入 1121 例病例和 1109 例对照的 IL-12B rs3212227，7 项研究纳入 1452 例病例和 2186 例对照的 IL-6 rs1800795，20 项研究纳入 4781 例病例和 4909 例对照的 TNF-α rs1800629，7 项研究纳入 1743 例病例和 2292 例对照的 TLR9 rs352140。结果显示，XRCC3 RS861539、TNF-α rs1800629 和 IL-6 rs1800795 多态性与宫颈癌总体易感性增加有关，但 MTHFR rs1801133、IL-12B rs3212227 和 TLR9 rs352140 多态性与宫颈癌易感性无关。
结论
荟萃分析表明，XRCC3 RS861539、TNF-α rs1800629 和 IL-6 rs1800795 与宫颈癌易感性相关，但 MTHFR rs1801133、IL-12B rs3212227 和 TLR9 rs352140 多态性与宫颈癌易感性无关。
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