Department of Dermatology, Pamukkale University, Denizli, Turkey.
J Eur Acad Dermatol Venereol. 2012 Jul;26(7):889-93. doi: 10.1111/j.1468-3083.2011.04186.x. Epub 2011 Jul 26.
Plantar warts are refractory to any form of treatment. High cure rates have been reported with a topical proprietary formulation consisting of 1% cantharidin, 5% podophyllotoxin and 30% salicylic acid (CPS). However, no data exists comparing the efficacy of this formulation with another treatment. Cryotherapy is a method that is also widely used in the treatment of plantar warts. Likewise, there is no evidence that it is more effective than any topical treatment.
We aim to compare the efficacy of topical CPS and cryotherapy in the treatment of plantar warts.
Patients with plantar warts were consecutively treated with either cryotherapy or topical CPS. Both treatments were performed every 2 weeks for up to five sessions. In patients without complete clearance, the therapy was switched to the other treatment option.
Twenty-six patients with a total of 134 warts were included. Fourteen patients were completely cleared of their warts with topical CPS, whereas only in five of 12 patients (41.7%) warts were completely cleared with cryotherapy (P=0.001). In seven patients without complete clearance, the therapy was switched to CPS. Four of these patients missed the follow-up. While the two of the remaining three patients were cleared of their warts, one patient's warts still failed to clear.
Topical CPS is more effective than cryotherapy in the treatment of plantar warts.
足底疣对任何形式的治疗都具有抗性。一种含有 1%斑蝥素、5%鬼臼毒素和 30%水杨酸的局部专利制剂（CPS）报告显示其治愈率很高。然而，目前尚无数据比较该制剂与其他治疗方法的疗效。冷冻疗法是一种广泛用于治疗足底疣的方法。同样，也没有证据表明它比任何局部治疗方法更有效。
我们旨在比较局部 CPS 和冷冻疗法治疗足底疣的疗效。
连续对足底疣患者进行冷冻疗法或局部 CPS 治疗。两种治疗方法每 2 周进行一次，最多进行五次。对于未完全清除的患者，将治疗方法切换到另一种治疗方案。
共纳入 26 名患者，总计 134 个疣。14 名患者的疣完全用 CPS 清除，而 12 名患者中的 5 名（41.7%）的疣完全用冷冻疗法清除（P=0.001）。在 7 名未完全清除的患者中，治疗方案切换到 CPS。这 7 名患者中有 4 名未参加随访。虽然剩余的 3 名患者中的 2 名疣被清除，但 1 名患者的疣仍未清除。
与冷冻疗法相比，局部 CPS 治疗足底疣更有效。
