University Podiatric Clinic, Complutense University of Madrid, Madrid, Spain.
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), University Podiatric Clinic, Complutense University of Madrid, Madrid, Spain.
J Med Virol. 2024 Sep;96(9):e29925. doi: 10.1002/jmv.29925.
A plantar wart is a benign hyperplasia that appears on the feet due to the human papillomavirus (HPV). One method used for the treatment of recalcitrant plantar warts, those lasting over 2 years or persisting after at least two treatment attempts, is the cantharidin (1%), podophyllin (5%), and salicylic acid (30%) formulation, also known as the CPS formulation. Although this method is in use, there are few studies on it. This study's objective was to ascertain its cure rate. For this retrospective observational study, we reviewed the medical records of patients treated with the CPS formulation at a podiatric clinic specializing in plantar wart treatment. Our sample size was 48 subjects. The CPS formulation had a cure rate of 62.5%. Out of the cured patients, 86.67% (26/30) required one or two applications. There was no observable correlation (p > 0.05) between wart resolution and virus biotype, evolution time, patient's morphological and clinical attributes, location, number of warts, or preceding treatments. The CPS formulation presents a relatively high efficacy rate for treating recalcitrant HPV plantar warts. Still, additional studies are necessary to evaluate its safety and efficiency.
足底疣是一种良性增生，由于人乳头瘤病毒（HPV）而在足部出现。一种用于治疗难治性足底疣（持续超过 2 年或至少两次治疗后仍持续存在）的方法是使用 1%斑蝥素、5%鬼臼毒素和 30%水杨酸的制剂，也称为 CPS 制剂。尽管这种方法正在使用，但对其的研究很少。本研究的目的是确定其治愈率。在这项回顾性观察研究中，我们回顾了专门治疗足底疣的足病诊所中使用 CPS 制剂治疗的患者的病历。我们的样本量为 48 名受试者。CPS 制剂的治愈率为 62.5%。在治愈的患者中，86.67%（26/30）需要应用一次或两次。疣的消退与病毒生物型、演变时间、患者的形态和临床特征、位置、疣的数量或先前的治疗之间没有观察到相关性（p＞0.05）。CPS 制剂治疗难治性 HPV 足底疣的疗效相对较高。然而，仍需要进一步的研究来评估其安全性和效率。
