Department of Dermatology, No.1 Hospital of China Medical University, Shenyang, China.
Dermatol Surg. 2011 Oct;37(10):1480-5. doi: 10.1111/j.1524-4725.2011.02092.x. Epub 2011 Jul 25.
The Q-switched alexandrite laser (QSAL) has been clinically proven to be effective in treating nevus of Ota, but a large-scale retrospective study with long-term follow-up has never been performed.
To evaluate the efficacy of the QSAL in treating nevus of Ota, the laser's long-term side effects, complications associated with the treatments, and the recurrence rate.
Eight hundred six patients (651 female, 155 male) with a diagnosis of nevus of Ota who had received a series of QSAL (wavelength 755 nm) treatments were recruited. The typical settings were fluences of 3.8 to 4.8 J/cm(2) and a spot size of 3 mm. Follow-ups were conducted via questionnaire with 590 patients who had completed the treatment at least 3 years earlier.
Overall, 93.9% of patients achieved complete clearance after an average of 5.2 sessions. All recurrences (0.8%) appeared beyond the previously treated sites. No long-term adverse effects, including hypopigmentation, hyperpigmentation, textural changes, and malignant transformation, were observed.
The QSAL is a safe and effective modality for treating nevus of Ota. Recurrence was rare and appeared beyond the previously treated sites. The authors have indicated no significant interest with commercial supporters.
Q-开关紫翠宝石激光（QSAL）已被临床证实对太田痣有效，但从未进行过大规模的回顾性研究和长期随访。
评估 QSAL 治疗太田痣的疗效、激光的长期副作用、治疗相关并发症以及复发率。
招募了 806 名（651 名女性，155 名男性）经诊断为太田痣的患者，他们接受了一系列 QSAL（波长 755nm）治疗。典型的设置为能量密度 3.8 至 4.8J/cm²，光斑大小为 3mm。通过问卷调查对至少 3 年前完成治疗的 590 名患者进行了随访。
总体而言，93.9%的患者在平均 5.2 次治疗后达到完全清除。所有复发（0.8%）均出现在之前治疗过的部位之外。未观察到长期不良反应，包括色素减退、色素沉着、质地改变和恶性转化。
QSAL 是治疗太田痣的一种安全有效的方法。复发罕见，且出现在之前治疗过的部位之外。作者表示与商业支持者没有重大利益关系。
