Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, China.
College of Medicine, Zhejiang University, Hangzhou 310000, China.
Biomed Res Int. 2020 Dec 4;2020:8824737. doi: 10.1155/2020/8824737. eCollection 2020.
In clinical practice, skin defects occur frequently due to various kinds of acute and chronic diseases. The standard treatment for these wounds is autografting, which usually results in complications such as scar formation and new wounds at donor sites. The advent of dermal substitutes has provided a novel method for wound repair, and rapid angiogenesis of the dermal substitutes is crucial for the graft to take. At present, many strategies have been developed to improve the process of vascularisation, some of which have shown promising potentials, but they could be very far from clinical applications. Most recently, negative-pressure wound therapy (NPWT) has been used extensively in clinical practice for wound care and management. It has been reported that NPWT reduces the time required for vascular ingrowth into the dermal substitute and improves graft take, indicating great potentials for wound repair. This article presents a comprehensive overview of the combined use of NPWT and dermal substitutes for tissue repair and regeneration. Relative concerns and prospects are also discussed.
在临床实践中，由于各种急性和慢性疾病，皮肤缺损经常发生。这些伤口的标准治疗方法是自体移植，但通常会导致供体部位形成疤痕和新伤口等并发症。真皮替代物的出现为伤口修复提供了一种新的方法，真皮替代物的快速血管生成对于移植物的成功至关重要。目前，已经开发了许多策略来改善血管化过程，其中一些已经显示出了有希望的潜力，但它们可能离临床应用还很远。最近，负压伤口治疗（NPWT）已广泛应用于临床伤口护理和管理。据报道，NPWT 可减少血管进入真皮替代物所需的时间，并提高移植物的成活率，这表明它在伤口修复方面有很大的潜力。本文全面介绍了 NPWT 与真皮替代物联合用于组织修复和再生的情况。同时还讨论了相对应的关注点和前景。
