特发性震颤与痉挛性发音障碍的共病率：一项病例对照研究。
Coprevalence of tremor with spasmodic dysphonia: a case-control study.
机构信息
Emory University School of Medicine, Atlanta, Georgia, USA.
出版信息
Laryngoscope. 2011 Aug;121(8):1752-5. doi: 10.1002/lary.21872.
Abstract
OBJECTIVES/HYPOTHESIS: The aim of this study was to define the coprevalence of tremor with spasmodic dysphonia (SD).
STUDY DESIGN
A single-institution, prospective, case-control study was performed from May 2010 to July 2010.
METHODS
Consecutive patients with SD (cases) and other voice disorders (controls) were enrolled prospectively. Each participant underwent a voice evaluation and an evaluation for tremor.
RESULTS
There were 146 voice disorder controls and 128 patients with SD enrolled. Of patients with SD 26% had vocal tremor, 21% had nonvocal tremor. Patients with SD were 2.8 times more likely to have coprevalent tremor than the control group (odds ratio = 2.81; 95% confidence interval, 1.55-5.08), and only 35% of patients with SD had been seen by a neurologist for the evaluation of dystonia and tremor.
CONCLUSIONS
Tremor is highly prevalent in patients with SD. It is important for each patient diagnosed with SD to undergo an evaluation for tremor, and this is especially important in patients diagnosed with vocal tremor.
摘要
目的/假设：本研究旨在确定痉挛性发音障碍（SD）与震颤的共同患病率。
研究设计
这是一项于 2010 年 5 月至 7 月进行的单机构、前瞻性、病例对照研究。
方法
连续纳入患有 SD（病例）和其他声音障碍（对照）的患者。每位参与者都接受了一项嗓音评估和震颤评估。
结果
纳入了 146 名声音障碍对照者和 128 名患有 SD 的患者。26%的 SD 患者有发声性震颤，21%的患者有非发声性震颤。与对照组相比，SD 患者出现共发性震颤的可能性高 2.8 倍（比值比=2.81；95%置信区间，1.55-5.08），且仅有 35%的 SD 患者曾因肌张力障碍和震颤的评估而就诊于神经科医生。
结论
震颤在 SD 患者中高度普遍。对于每位被诊断为 SD 的患者，进行震颤评估非常重要，而对于诊断为发声性震颤的患者尤其重要。
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