Ten Cate J M
Department of Cariology & Endodontology, Academic Center for Dentistry Amsterdam, (ACTA), The Netherlands.
J Dent Res. 1990 Feb;69 Spec No:614-9; discussion 634-6. doi: 10.1177/00220345900690S120.
The recent literature extensively describes the role of ambient fluoride in the de- and remineralization of dental enamel. Fluoride in sub-ppm concentrations is effective in promoting mineral deposition and inhibiting mineral dissolution. The latter phenomenon is most likely attributable to the concomitant precipitation of a fluoride-rich mineral phase which inhibits further dissolution. These fundamental processes result in an inhibition of enamel demineralization and an enhancement of enamel lesion remineralization. Alternatively, fluoride may also induce the 'arrestment' of enamel lesions. For the in vivo patterns and the effects of caries-preventive substances to be studied, de- and remineralization can best be examined with a pH-cycling system in which the pH depressions occurring in the oral environment are mimicked in a laboratory model. Such an approach has proved useful in developing optimal fluoride schemes which can be tested in animal, intraoral, and clinical studies.
近期文献广泛描述了环境氟化物在牙釉质脱矿和再矿化过程中的作用。亚百万分之一浓度的氟化物能有效促进矿物质沉积并抑制矿物质溶解。后一种现象很可能归因于富含氟化物的矿相同时沉淀，从而抑制了进一步溶解。这些基本过程导致牙釉质脱矿受到抑制，牙釉质病变再矿化得到增强。另外，氟化物也可能促使牙釉质病变“停止发展”。为了研究体内模式以及防龋物质的作用，脱矿和再矿化最好通过pH循环系统进行检测，该系统能在实验室模型中模拟口腔环境中发生的pH降低情况。事实证明，这种方法有助于制定最佳的氟化物方案，可在动物、口腔内和临床研究中进行测试。
