Satou Ryouichi, Odaka Kento, Sako Ryo, Ando Masatoshi, Sugihara Naoki
Department of Epidemiology and Public Health, Tokyo Dental College, Tokyo 101-0061, Japan.
Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, IN 46202, USA.
Materials (Basel). 2024 Nov 23;17(23):5731. doi: 10.3390/ma17235731.
An intraoral fluoride-releasing device (IFRD) is a cost-effective tool for introducing fluoride into the oral cavity. It allows prolonged uptake of low concentrations of fluoride into teeth. We developed a new IFRD using 3D additive manufacturing and a new low-release fluoride gel. Gels for IFRDs were synthesized from hydroxyethyl cellulose (SE600) and cationic hydroxyethyl cellulose (L200). We compared the effects of the new cationic fluoride slow-release gel and non-cationic gel on enamel acid resistance in vitro. Cationization significantly increased fluoride ion concentration, as evident from its concentrations of 0.68 ± 0.08 ppm for SE600 and 4.24 ± 0.83 ppm for L200 after 60 min of immersion in distilled water. In addition, the acid resistance of bovine tooth enamel post-application was analyzed by measuring tooth loss, mineral loss (ΔZ), and lesion depth (Ld) using polarized light microscopy, electron microscopy, and micro-radiography. Compared to the SE600 group, the cationic L200 group had significantly reduced ΔZ and Ld, enhancing enamel acid resistance. This device could be implemented in areas where adequate oral care is challenging, including preventive dentistry, ward management, nursing homes, and dental clinic visits.
口腔内释氟装置（IFRD）是一种将氟化物引入口腔的经济有效工具。它能使牙齿长时间摄取低浓度的氟化物。我们利用3D增材制造技术和一种新型低释放氟凝胶开发了一种新型IFRD。用于IFRD的凝胶由羟乙基纤维素（SE600）和阳离子羟乙基纤维素（L200）合成。我们比较了新型阳离子氟缓释凝胶和非阳离子凝胶对牙釉质体外抗酸性的影响。阳离子化显著提高了氟离子浓度，在蒸馏水中浸泡60分钟后，SE600的氟离子浓度为0.68±0.08 ppm，L200的氟离子浓度为4.24±0.83 ppm，这一点很明显。此外，使用偏光显微镜、电子显微镜和微放射摄影术测量牙齿损失、矿物质损失（ΔZ）和病变深度（Ld），分析应用后牛牙釉质的抗酸性。与SE600组相比，阳离子L200组的ΔZ和Ld显著降低，增强了牙釉质的抗酸性。该装置可应用于口腔护理条件有限的地区，包括预防牙科、病房管理、养老院和牙科诊所就诊。
