Groeneveld A, Van Eck A A, Backer Dirks O
Department of Community Dental Health and Epidemiology, Netherlands Institute for Preventive Health Care, Leiden.
J Dent Res. 1990 Feb;69 Spec No:751-5; discussion 820-3. doi: 10.1177/00220345900690S145.
A longitudinal study of children from ages 7 to 18 showed that, if enamel lesions were included, the overall number was the same in fluoridated and non-fluoridated areas. However, a significant reducing effect of pre-eruptive fluoride could be seen in the number of dentinal lesions in a fluoridated area, provided that fluoride was also consumed post-eruptively for a considerable period of time. A precise estimation of both pre- and post-eruptive effects was obtained when teeth were classified according to their eruption time as related to the onset of water fluoridation. About 66% of the greatest reduction in pit and fissure caries came from pre-eruptive fluoride, while in smooth surfaces, this effect was reduced to 25%. In approximal surfaces, the reduction was due half to pre- and half to post-eruptive fluoride. Post-eruptive fluoride became more important with decreasing severity of caries attack. Thus, assuming a continuing decline in dental caries, the majority of such populations will benefit most from the use of topical fluorides. However, in high-risk groups, supplementation of pre-eruptive fluoride can still be of major importance.
一项针对7至18岁儿童的纵向研究表明，如果将釉质病变包括在内，氟化地区和非氟化地区的总数相同。然而，在氟化地区，只要在牙齿萌出后相当长一段时间内也摄入氟化物，就可以看到萌出前氟化物对牙本质病变数量有显著的减少作用。当根据牙齿萌出时间与水氟化开始时间的关系对牙齿进行分类时，可以精确估计萌出前和萌出后的影响。窝沟龋减少最多的约66%来自萌出前氟化物，而在光滑面，这种影响降至25%。在邻面，减少一半归因于萌出前氟化物，一半归因于萌出后氟化物。随着龋病攻击严重程度的降低，萌出后氟化物变得更加重要。因此，假设龋齿持续减少，这类人群中的大多数将从使用局部氟化物中获益最多。然而，在高危人群中，补充萌出前氟化物仍然至关重要。
