Groeneveld A
Community Dent Oral Epidemiol. 1985 Jun;13(3):159-63. doi: 10.1111/j.1600-0528.1985.tb00434.x.
The aim of this study was to examine longitudinally the effect of water fluoridation on the prevalence of enamel lesions in children 7-18 yr of age. 93 children in Tiel (1 ppm F-) and 103 children in Culemborg (0.1 ppm F-) were examined every other year at 7, 9, 11, 13 and 15 yr of age. A supplementary examination was carried out when these children reached the age of 18. Children in Tiel had access to water fluoridation from birth. The total number of lesions, including enamel lesions, on the buccal as well as on the occlusal surfaces was approximately the same in both areas in children 15 and 18 yr of age. Approximal lesions were scored on standardized bitewing radiographs. A large proportion of enamel lesions could not be detected on radiographs. In a fluoridated area a high percentage of all lesions remain in the stage of enamel caries lesions. On buccal surfaces 93% and on approximal surfaces 86% of all lesions had not progressed into the dentin. In Culemborg these percentages were 65 for approximal as well as for buccal surfaces. At the initiation of lesions, at younger ages, only a small retardation of the process was observed, but caries progression beyond the stage of enamel caries was markedly reduced in the fluoridated area. No pre-eruptive effect could be observed if the total number of lesions, including enamel lesions, from Tiel and Culemborg were compared.
本研究的目的是纵向考察水氟化对7至18岁儿童牙釉质病变患病率的影响。对铁尔（氟含量1 ppm）的93名儿童和库伦堡（氟含量0.1 ppm）的103名儿童，在其7岁、9岁、11岁、13岁和15岁时每隔一年进行检查。当这些儿童满18岁时进行了补充检查。铁尔的儿童从出生起就可使用含氟水。在15岁和18岁的儿童中，颊面和咬合面包括牙釉质病变在内的病变总数在两个地区大致相同。邻面病变通过标准化的咬合翼片进行评分。很大一部分牙釉质病变在X线片上无法检测到。在氟化地区，所有病变中有很大比例仍处于牙釉质龋病变阶段。在颊面，所有病变中有93%未进展至牙本质，在邻面这一比例为86%。在库伦堡，邻面和颊面的这一比例均为65%。在病变初期，即儿童较小时，仅观察到病变进程有轻微延缓，但在氟化地区，龋病进展超过牙釉质龋阶段的情况明显减少。如果比较铁尔和库伦堡包括牙釉质病变在内的病变总数，未观察到萌出前的影响。
