Miskulin M, Moati F, Robert A M, Monteil R, Guilbaud G
J Med. 1978;9(5):405-22.
Several serum proteins, such as prealbumin, protease inhibitors, immunoglobulins, metalloproteins and inflammatory glycoproteins were determined in the sera of heavily burnt patients by radial immunodiffusion. An increase of acute phase reactant glycoproteins (orsomucoid, haptoglobin, haemopexin, C-reactive protein), C3-complement, immunoglobulins, prealbumin and of the protease inhibitors (a1-antitrypsin, a2-macroglobulin) was found. For some proteins, such as prealbumin, haemopexin, immunoglobulins, this increase was preceeded by a decrease on days 3 to 5 post-burn. The time course of the increase was variable, faster for some patients and slower for others: orosomucoid, C-reactive protein, C3-complement reached peak values between days 6 and 8; immunoglobulins and hemopexin decreased then towards normal values. No significant increase was found for ceruloplasmin, transferrin, beta2-glycoprotein, a2-SH glycoprotein and GC-globulin. It is proposed that the selective overproduction of the above mentioned proteins may be related to the stimulation of acute-phase reactant protein synthesis by the liver as a result of tissue breakdown produced by the circulating proteases and especially by elastases and collagenases as was shown previously (Miskulin et al., 1978; Moati et al., 1978a).
采用放射免疫扩散法测定了重度烧伤患者血清中的几种蛋白质，如前白蛋白、蛋白酶抑制剂、免疫球蛋白、金属蛋白和炎性糖蛋白。发现急性期反应性糖蛋白（如血清类黏蛋白、触珠蛋白、血红素结合蛋白、C反应蛋白）、C3补体、免疫球蛋白、前白蛋白和蛋白酶抑制剂（α1-抗胰蛋白酶、α2-巨球蛋白）有所增加。对于某些蛋白质，如前白蛋白、血红素结合蛋白、免疫球蛋白，在烧伤后第3至5天出现下降，随后才增加。增加的时间进程各不相同，有些患者较快，有些患者较慢：血清类黏蛋白、C反应蛋白、C3补体在第6至8天达到峰值；免疫球蛋白和血红素结合蛋白随后降至正常水平。铜蓝蛋白、转铁蛋白、β2-糖蛋白、α2-SH糖蛋白和GC球蛋白未发现明显增加。有人提出，上述蛋白质的选择性过度产生可能与肝脏受急性期反应蛋白合成刺激有关，这种刺激是由循环蛋白酶尤其是弹性蛋白酶和胶原酶引起的组织分解所致，如先前所示（米斯库林等人，1978年；莫阿蒂等人，1978a）。
