Alvarez-Hernández Everardo, Zamudio-Lerma Jorge A, Burgos-Martínez Gabriela, Alvarez-Etchegaray Sandra E, Pelaez-Ballestas Ingris, Vázquez-Mellado J
Servicio de Reumatología, Hospital General de México, México D.F., México.
Reumatol Clin. 2009 May-Jun;5(3):103-8. doi: 10.1016/j.reuma.2008.11.011. Epub 2009 Apr 2.
In gout there are few instruments validated for the evaluation of activity, functional capacity or quality of life. It is not known if generic instruments such as the MOS-20, or specific for other illnesses, such as the AIMS, can be applied to patients with Gout.
To evaluate the clinimetric characteristic of the MOS-20 and AIMS questionnaires, and their correlation with HAQ-DI, as well as with clinical variables in patient with tophaceous gout (TG).
49 patients with TG were included. Demographic and clinical variables were obtained. The 3 questionnaires were applied at the basal evaluation. A second evaluation was applied to 20 patients, 8 weeks later.
All patients were male. The time of since onset of the illness was 14.9±8.3 years. The HAQ-DI was 0.43±0.56 with an alpha of Cronbach (αC) of 0.95 and the intraclass correlation coefficient (ICC) was 0.86. The MOS-20 had an αC of 0.68 to 1.0 and a ICC of 0.27 to 0.61 between the several components. The AIMS had an αC of 0.66 to 0.96, and a ICC of 0.11 to 0.79 between the several components. Reliability was better between the physical components in MOS-20 and AIMS. The MOS-20, AIMS and the HAQ-DI correlated with the presence of joints with functional limitation. There weren't any significant differences among the patients with inflamed joints, nor in those with tophi. The HAQ-DI was best correlated with the physical component than with the mental component of the AIMS and the MOS-20.
The AIMS, the MOS-20 and the HAQ-DI are useful in measuring the functional capacity and the quality of life in patient with TG.
在痛风领域，用于评估疾病活动度、功能能力或生活质量的有效工具较少。目前尚不清楚诸如MOS-20这类通用工具，或其他疾病专用的工具，如AIMS，是否可应用于痛风患者。
评估MOS-20和AIMS问卷的临床测量特性，及其与健康评估问卷残疾指数（HAQ-DI）的相关性，以及与痛风石性痛风（TG）患者临床变量的相关性。
纳入49例TG患者。获取人口统计学和临床变量。在基础评估时应用这3种问卷。8周后对20例患者进行第二次评估。
所有患者均为男性。疾病发病时间为14.9±8.3年。HAQ-DI为0.43±0.56，克朗巴哈系数（αC）为0.95，组内相关系数（ICC）为0.86。MOS-20的αC在0.68至1.0之间，各分量之间的ICC在0.27至0.61之间。AIMS的αC在0.66至0.96之间，各分量之间的ICC在0.11至0.79之间。MOS-20和AIMS的躯体分量之间的信度更好。MOS-20、AIMS和HAQ-DI与存在功能受限的关节相关。在有炎症关节的患者之间以及有痛风石的患者之间均无显著差异。HAQ-DI与AIMS和MOS-20的躯体分量的相关性优于与精神分量的相关性。
AIMS、MOS-20和HAQ-DI可用于测量TG患者的功能能力和生活质量。
