Hernández-Molina Gabriela, Michel-Peregrina Martha L
Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.
Reumatol Clin. 2011 Mar-Apr;7(2):130-4. doi: 10.1016/j.reuma.2010.07.005. Epub 2011 Feb 17.
Sjögren's syndrome (SS) is an autoimmune disorder affecting primarily the exocrine glands, leading to keratoconjunctivitis sicca (KCS) and xerostomia, but that can also include extraglandular features(1). Due the anatomical, physiological and pathological similarity between the pancreas and the salivary glands, it has been described that the pancreas it is not exempt from the damage produced by this syndrome. Some authors have assessed pancreatic involvement of SS by analyzing the histopathological changes, evaluating the pancreatic endocrine and exocrine function (serum pancreatic enzymes, elastase, lipase or trypsin determinations, N-benzoyl-L-tyrosyl-para-aminobenzoic acid excretion test, etc), searching specific pancreatic antibodies (antiductal) or performing endoscopic retrograde colangiopancreatography or noninvasive imaging studies such as computed tomography or ultrasound. Herein we review the literature regarding the prevalence and type of pancreatic involvement in the SS and we discuss the differential diagnosis with multiorganic Lymphoproliferative Syndrome.
干燥综合征（SS）是一种主要影响外分泌腺的自身免疫性疾病，可导致角结膜干燥症（KCS）和口干症，但也可能包括腺体外表现（1）。由于胰腺和唾液腺在解剖学、生理学和病理学上具有相似性，已有描述表明胰腺也难免受到该综合征造成的损害。一些作者通过分析组织病理学变化、评估胰腺内分泌和外分泌功能（血清胰酶、弹性蛋白酶、脂肪酶或胰蛋白酶测定、N-苯甲酰-L-酪氨酰-对氨基苯甲酸排泄试验等）、寻找特异性胰腺抗体（抗导管抗体）或进行内镜逆行胰胆管造影术或计算机断层扫描或超声等非侵入性影像学检查来评估干燥综合征患者的胰腺受累情况。在此，我们回顾了关于干燥综合征中胰腺受累的患病率和类型的文献，并讨论了与多器官淋巴增殖综合征的鉴别诊断。
