干燥综合征和类风湿关节炎患者外分泌胰腺功能的对照研究。

A controlled study of the exocrine pancreatic function in Sjögren's syndrome and rheumatoid arthritis.

作者信息

Gobelet C, Gerster J C, Rappoport G, Hiroz C A, Maeder E

出版信息

Clin Rheumatol. 1983 Jun;2(2):139-43. doi: 10.1007/BF02032170.

DOI:10.1007/BF02032170

PMID:6331966

Abstract

The exocrine pancreatic function has been estimated using the N-benzoyl-L-Tyrosyl para-amino-benzoic acid test (NBT PABA test) and by measuring the trypsinemia by radio-immunoassay (RIA trypsinemia) in nonselected cases of Sjögren's syndrome (SS) and seropositive rheumatoid arthritis (RA) in comparison with normal controls. The NBT PABA test was pathological in 37,5% of SS and 35% of RA patients but in none of the controls. The RIA trypsinemia was found to be high in 6,2% of SS and 45% of RA patients. These findings suggest that exocrine pancreatic function is impaired in some SS and RA cases. However, this exocrine pancreatic defect was clinically silent in all patients.

摘要

在非选择性干燥综合征（SS）和血清反应阳性类风湿关节炎（RA）患者中，通过N-苯甲酰-L-酪氨酰对氨基苯甲酸试验（NBT PABA试验）并采用放射免疫分析法（RIA胰蛋白酶血症法）测定胰蛋白酶血症，以评估外分泌胰腺功能，并与正常对照组进行比较。NBT PABA试验在37.5%的SS患者和35%的RA患者中呈病理性，但在所有对照组中均未出现。RIA胰蛋白酶血症在6.2%的SS患者和45%的RA患者中较高。这些发现表明，部分SS和RA病例存在外分泌胰腺功能受损。然而，所有患者的这种外分泌胰腺缺陷在临床上均无表现。