Florida Veterinary Behavior Service, PO Box 210636, Royal Palm Beach, FL 33421, USA.
Vet J. 2012 Jun;192(3):472-5. doi: 10.1016/j.tvjl.2011.06.029. Epub 2011 Jul 26.
A cross-sectional study was performed in order to examine the association between canine aggression to familiar people and serum concentrations of total thyroxine (TT4), free thyroxine (fT4), thyroxine autoantibodies (T4AA), total triiodothyronine (TT3), free triiodothyronine (fT3), triiodothyronine autoantibodies (T3AA), thyroid stimulating hormone (TSH), and thyroglobulin autoantibodies (TgAA). The subjects were 31 dogs historically aggressive to familiar people and 31 dogs with no history of aggression. Behavioral evaluation and physical examination were completed for each dog in addition to a complete blood count, serum chemistry panel, TT4, fT4 by equilibrium dialysis, TT3, fT3, TgAA, T3AA, and T4AA. Significant differences were found between the two groups with respect to only T4AA, which was increased in the aggressive group, but the concentrations for both groups were within the normal reference range. There were no differences between the two groups in the thyroid analytes most commonly measured by veterinary practitioners evaluating thyroid function in dogs. The results of this study revealed no significant difference between aggressive and non-aggressive dogs in the thyroid concentrations most commonly used to diagnose canine hypothyroidism.
本研究采用横断面研究，旨在探讨犬只对熟人的攻击行为与总甲状腺素（TT4）、游离甲状腺素（fT4）、甲状腺素自身抗体（T4AA）、总三碘甲状腺原氨酸（TT3）、游离三碘甲状腺原氨酸（fT3）、三碘甲状腺原氨酸自身抗体（T3AA）、促甲状腺激素（TSH）和甲状腺球蛋白自身抗体（TgAA）之间的相关性。受试犬为 31 只具有攻击熟人历史的犬和 31 只无攻击史的犬。除了全血细胞计数、血清化学分析、TT4、平衡透析法 fT4、TT3、fT3、TgAA、T3AA 和 T4AA 外，还对每只犬进行了行为评估和体格检查。两组之间仅 T4AA 存在显著差异，攻击组 T4AA 升高，但两组的浓度均在正常参考范围内。两组之间兽医在评估犬甲状腺功能时最常测量的甲状腺分析物无差异。本研究结果显示，诊断犬甲状腺功能减退症时最常用的甲状腺浓度在攻击犬和非攻击犬之间无显著差异。
