van Geffen Cindy, Bavegems Valérie, Duchateau Luc, De Roover Katrien, Daminet Sylvie
Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Vet J. 2006 Jul;172(1):135-40. doi: 10.1016/j.tvjl.2005.03.007.
Numerous factors including non-thyroidal systemic diseases and drug administration can significantly alter canine thyroid function test results. Furthermore, the importance of breed specific variations has probably been underestimated. In this study, total thyroxine (TT4), free thyroxine (FT4), canine endogenous thyroid stimulating hormone (cTSH) serum concentrations and thyroglobulin autoantibodies (TgAA) were determined in a population of healthy whippets and compared to a control group of different breeds. Mean TT4 values were significantly lower in the whippets but no significant differences were seen between whippets and control dogs for FT4 and for cTSH. The prevalence of serum TgAA in the whippets was 2%, and this was not significantly different from the controls. The results suggest a breed variation for TT4, but not for FT4, cTSH and TgAA serum concentrations in whippets. Serum thyroid hormone concentrations were also compared between trained and non-trained whippets and it was concluded that regular training did not seem to have any significant influence.
包括非甲状腺系统性疾病和药物使用在内的众多因素会显著改变犬甲状腺功能测试结果。此外，品种特异性差异的重要性可能被低估了。在本研究中，测定了一群健康惠比特犬的总甲状腺素（TT4）、游离甲状腺素（FT4）、犬内源性促甲状腺激素（cTSH）血清浓度和甲状腺球蛋白自身抗体（TgAA），并与不同品种的对照组进行比较。惠比特犬的平均TT4值显著较低，但在FT4和cTSH方面，惠比特犬与对照犬之间未观察到显著差异。惠比特犬血清TgAA的患病率为2%，与对照组无显著差异。结果表明，惠比特犬的TT4存在品种差异，但FT4、cTSH和TgAA血清浓度不存在品种差异。还比较了训练过的和未训练过的惠比特犬的血清甲状腺激素浓度，得出的结论是定期训练似乎没有任何显著影响。
