Mahto M, Evans-Jones J, Zia S, Robinson T I, Rothburn M M, Mallinson H
East Cheshire NHS Trust, Macclesfield District General Hospital, Macclesfield, UK.
Int J STD AIDS. 2011 Aug;22(8):471-3. doi: 10.1258/ijsa.2011.011102.
We describe the use of a new molecular assay for Trichomonas vaginalis (TV), the Gen-Probe Aptima TV (ATV) in female attendees at community clinics, a genitourinary (GU) medicine clinic and a prison GU medicine service. Positivity rates at community clinics and GU medicine were 0/382 (0%) and 3/358 (0.8%, 95% confidence interval [CI] 0-1.7%), respectively. Positivity was significantly higher, 29/269 (10.8%, 95% CI 7.1-14.5%), odds ratio (OR) 14.3 (4.11 < OR < 59.55), in those tested at the prison. A questionnaire survey of English GU medicine clinics and data from the UK Health Protection Agency (HPA) for England both demonstrated the large variation in case rates by region and testing methods employed. Higher rates were seen in women, in prison GU medicine services and in London GU medicine clinics. The ATV assay is now CE-marked (Conformité Européenne) and so a larger prospective study of its potential application is warranted.
我们描述了一种针对阴道毛滴虫（TV）的新型分子检测方法——Gen-Probe Aptima TV（ATV）在社区诊所、泌尿生殖医学诊所及监狱泌尿生殖医学服务机构女性就诊者中的应用情况。社区诊所和泌尿生殖医学诊所的阳性率分别为0/382（0%）和3/358（0.8%，95%置信区间[CI]为0 - 1.7%）。在监狱接受检测者的阳性率显著更高，为29/269（10.8%，95%CI为7.1 - 14.5%），优势比（OR）为14.3（4.11 < OR < 59.55）。对英国泌尿生殖医学诊所的问卷调查以及英国卫生防护局（HPA）提供的英格兰地区数据均显示，病例发生率因地区和所采用的检测方法存在很大差异。女性、监狱泌尿生殖医学服务机构及伦敦泌尿生殖医学诊所的发病率更高。ATV检测方法现已获得CE认证（欧洲符合性认证），因此有必要对其潜在应用开展更大规模的前瞻性研究。
