Peter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
J Immunol. 2011 Sep 1;187(5):2067-71. doi: 10.4049/jimmunol.1100833. Epub 2011 Jul 27.
The RGS1 gene is associated with celiac disease, multiple sclerosis, and type I diabetes, which are all T cell-mediated pathologies, yet there is no reported analysis of regulator of G protein signaling (RGS)1 biology in human T cells. This study shows that RGS1 expression is substantially higher in T cells from human gut versus peripheral blood and that this can be exaggerated in intestinal inflammation. Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines, whereas RGS1 depletion selectively enhances such chemotaxis in gut T cells and impairs their colitogenic potential. These findings provide a revised framework in which to view the linkage of RGS1 to inflammatory disease.
RGS1 基因与乳糜泻、多发性硬化症和 1 型糖尿病有关，这些都是 T 细胞介导的疾病，但目前尚未有关于人类 T 细胞中 G 蛋白信号转导调节因子（RGS）1 生物学的报道分析。本研究表明，与外周血相比，人类肠道 T 细胞中 RGS1 的表达水平显著升高，而在肠道炎症中这种升高更为明显。RGS1 水平升高会显著降低 T 细胞向淋巴归巢趋化因子的迁移，而 RGS1 耗竭则选择性地增强肠道 T 细胞的趋化作用，并损害其结肠炎发病潜能。这些发现为我们提供了一个新的框架，以观察 RGS1 与炎症性疾病的关联。
